|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0010453,
umls-concept:C0013227,
umls-concept:C0026769,
umls-concept:C0030705,
umls-concept:C0035647,
umls-concept:C0036536,
umls-concept:C0036537,
umls-concept:C0162340,
umls-concept:C0205225,
umls-concept:C0289884,
umls-concept:C0332293,
umls-concept:C0348024,
umls-concept:C1367714
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pubmed:issue |
1-2
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|
pubmed:dateCreated |
2011-5-11
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pubmed:abstractText |
Autoimmune thyroid disease (AITD) has been reported in patients with multiple sclerosis (MS) receiving interferon-beta (IFN-?), but not in those receiving Glatiramer acetate (GA). CXCL10 is a chemokine playing a pathogenetic role in AITD and MS. Our aim was to evaluate the effects on CXCL10 secretion of IFN-? and GA, alone and in combination with TNF-?, in primary cultures of thyrocytes (PCT). Significant and dose-dependent secretions of CXCL10 were induced by IFN-? but not GA. TNF-? synergistically increased IFN-? induced CXCL10 secretion. These results may provide an explanation for the occurrence of AITD during IFN-?, but not during GA, treatment for MS.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1872-8421
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|
pubmed:author |
pubmed-author:BergamaschiRobertoR,
pubmed-author:ChiovatoLucaL,
pubmed-author:CoperchiniFrancescaF,
pubmed-author:GhilottiStefaniaS,
pubmed-author:La MannaLuigiL,
pubmed-author:LagonigroMaria StefaniaMS,
pubmed-author:MagriFlaviaF,
pubmed-author:OlivieroAntonioA,
pubmed-author:PagliariMaria TeresaMT,
pubmed-author:RotondiMarioM,
pubmed-author:StufanoFrancescaF,
pubmed-author:ZerbiniFrancescaF
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier B.V. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
234
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
161-4
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|
pubmed:meshHeading |
|
|
pubmed:year |
2011
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|
pubmed:articleTitle |
Interferon-? but not Glatiramer acetate stimulates CXCL10 secretion in primary cultures of thyrocytes: a clue for understanding the different risks of thyroid dysfunctions in patients with multiple sclerosis treated with either of the two drugs.
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|
pubmed:affiliation |
Unit of Internal Medicine and Endocrinology, Fondazione Salvatore Maugeri I.R.C.C.S., ISPESL Laboratory for Endocrine Disruptors and Chair of Endocrinology, University of Pavia, Italy.
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pubmed:publicationType |
Journal Article
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