21370437

Source:http://linkedlifedata.com/resource/pubmed/id/21370437

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0206153, umls-concept:C0242596, umls-concept:C0332152, umls-concept:C0442726, umls-concept:C1511790, umls-concept:C2323499
pubmed:issue	1
pubmed:dateCreated	2011-5-10
pubmed:abstractText	Previous studies to evaluate minimal disease in acute lymphoblastic leukemia (ALL) after treatment have relied on the diagnostic specimen to develop patient-specific analytical probes. The diagnostic specimen is often not available in a tertiary setting; therefore, we evaluated the use of flow cytometry (FCM) using a "difference from normal" approach to detect residual disease prior to myeloablative allogeneic hematopoietic cell transplantation (HCT). Among 116 pediatric patients with ALL who were in morphological remission at time of transplant, we found that those patients who had detectable residual disease by FCM prior to HCT experienced significantly inferior outcome.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101186624
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Jul
pubmed:issn	1545-5017
pubmed:author	pubmed-author:FosterJennifer HJH, pubmed-author:HawkinsDouglas SDS, pubmed-author:LokenMichael RMR, pubmed-author:ThomsonBlytheB, pubmed-author:WellsDenise ADA
pubmed:copyrightInfo	Copyright © 2011 Wiley-Liss, Inc.
pubmed:issnType	Electronic
pubmed:day	15
pubmed:volume	57
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	163-5
pubmed:meshHeading	pubmed-meshheading:21370437-Adolescent, pubmed-meshheading:21370437-Adult, pubmed-meshheading:21370437-Child, pubmed-meshheading:21370437-Child, Preschool, pubmed-meshheading:21370437-Disease-Free Survival, pubmed-meshheading:21370437-Female, pubmed-meshheading:21370437-Hematopoietic Stem Cell Transplantation, pubmed-meshheading:21370437-Humans, pubmed-meshheading:21370437-Infant, pubmed-meshheading:21370437-Male, pubmed-meshheading:21370437-Neoplasm, Residual, pubmed-meshheading:21370437-Precursor Cell Lymphoblastic Leukemia-Lymphoma, pubmed-meshheading:21370437-Retrospective Studies, pubmed-meshheading:21370437-Survival Rate, pubmed-meshheading:21370437-Transplantation, Homologous
pubmed:year	2011
pubmed:articleTitle	Minimal residual disease detected prior to hematopoietic cell transplantation.
pubmed:affiliation	Department of Pediatric Hematology/Oncology, Texas Children's Cancer Center/Baylor College of Medicine, Houston, Texas, USA.
pubmed:publicationType	Journal Article