Linked Life Data

21368406

Source:http://linkedlifedata.com/resource/pubmed/id/21368406

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 3
pubmed:dateCreated
2011-3-3
pubmed:abstractText
In (1R,3S)-6,7-dimethoxy-3-(methoxydiphenylmethyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline, C(31)H(31)NO(3), (I), and (1R,3S)-2-benzyl-3-[diphenyl(trimethylsiloxy)methyl]-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline, C(40)H(43)NO(3)Si, (II), the absolute configurations have been confirmed to be R and S at the isoquinoline 1- and 3-positions, respectively, by NMR spectroscopy experiments. Both structures have monoclinic (P2(1)) symmetry and the N-containing six-membered ring assumes a half-chair conformation. The asymmetric unit of (I) contains one molecule, while (II) has two molecules within the asymmetric unit. These structures are of interest with respect to the conformation around the exocyclic C-C bond: (I) displays an ap (antiperiplanar) conformation, while (II) displays an sc-exo (synclinal) conformation around this bond. These conformations are significant for stereocontrol when these compounds are used as catalysts. Various C-H...? and C-H...O bonds link the molecules together in the crystal structure of (I). In the crystal structure of (II), three intermolecular C-H...? hydrogen bonds help to establish the packing.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1600-5759
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
o100-3
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Optically active diaryl tetrahydroisoquinoline derivatives.
pubmed:affiliation
School of Pharmacy and Pharmacology, University of KwaZulu Natal, Durban, South Africa.
pubmed:publicationType
Journal Article