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rdf:type |
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lifeskim:mentions |
umls-concept:C0003009,
umls-concept:C0016030,
umls-concept:C0017262,
umls-concept:C0018787,
umls-concept:C0056695,
umls-concept:C0185117,
umls-concept:C0442805,
umls-concept:C1120843,
umls-concept:C1366765,
umls-concept:C1424662,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
2011-6-13
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pubmed:abstractText |
Angiotensin II (AngII) is involved in extracellular matrix (ECM) accumulation contributing to heart failure. Periostin, a 90 kDa ECM protein, is a key regulator of cardiac fibrosis, and its expression is significantly higher in failing hearts. We determined the modulatory effect of AngII on periostin level and explored the possible signal transduction mechanism.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II Type 1 Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/CREB1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP Response...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Guanine Nucleotide Exchange Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Losartan,
http://linkedlifedata.com/resource/pubmed/chemical/Madh2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Madh3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Mapk1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Postn protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Rasgrp1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Smad2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Smad3 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Tgfb1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1755-3245
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
80-9
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pubmed:meshHeading |
pubmed-meshheading:21367774-Analysis of Variance,
pubmed-meshheading:21367774-Angiotensin II,
pubmed-meshheading:21367774-Angiotensin II Type 1 Receptor Blockers,
pubmed-meshheading:21367774-Animals,
pubmed-meshheading:21367774-Cell Adhesion Molecules,
pubmed-meshheading:21367774-Cells, Cultured,
pubmed-meshheading:21367774-Cyclic AMP Response Element-Binding Protein,
pubmed-meshheading:21367774-DNA-Binding Proteins,
pubmed-meshheading:21367774-Fibroblasts,
pubmed-meshheading:21367774-Fibrosis,
pubmed-meshheading:21367774-Guanine Nucleotide Exchange Factors,
pubmed-meshheading:21367774-Infusions, Subcutaneous,
pubmed-meshheading:21367774-Losartan,
pubmed-meshheading:21367774-Male,
pubmed-meshheading:21367774-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:21367774-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:21367774-Myocardium,
pubmed-meshheading:21367774-Phosphorylation,
pubmed-meshheading:21367774-Protein Kinase Inhibitors,
pubmed-meshheading:21367774-RNA, Messenger,
pubmed-meshheading:21367774-RNA Interference,
pubmed-meshheading:21367774-Rats,
pubmed-meshheading:21367774-Rats, Sprague-Dawley,
pubmed-meshheading:21367774-Signal Transduction,
pubmed-meshheading:21367774-Smad2 Protein,
pubmed-meshheading:21367774-Smad3 Protein,
pubmed-meshheading:21367774-Time Factors,
pubmed-meshheading:21367774-Transfection,
pubmed-meshheading:21367774-Transforming Growth Factor beta1,
pubmed-meshheading:21367774-Up-Regulation,
pubmed-meshheading:21367774-p38 Mitogen-Activated Protein Kinases,
pubmed-meshheading:21367774-ras Proteins
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pubmed:year |
2011
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pubmed:articleTitle |
Angiotensin II increases periostin expression via Ras/p38 MAPK/CREB and ERK1/2/TGF-?1 pathways in cardiac fibroblasts.
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pubmed:affiliation |
Department of Physiology and Pathophysiology, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100191, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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