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pubmed-article:21367726pubmed:abstractTextThe widely used 23-valent plain polysaccharide vaccine (23vP) has limited effectiveness, produces short-lived immune responses, and induces attenuated antibody production after subsequent challenge with pneumococcal vaccines. Our goal was to examine whether priming with the 7-valent pneumococcal conjugate vaccine (PCV7) could enhance the immunogenicity of 23vP for the PCV7 serotypes and to investigate whether 23vP induced hyporesponsiveness could be overcome using PCV7.lld:pubmed
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pubmed-article:21367726pubmed:dateRevised2011-7-21lld:pubmed
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pubmed-article:21367726pubmed:articleTitleA randomized study comparing combined pneumococcal conjugate and polysaccharide vaccination schedules in adults.lld:pubmed
pubmed-article:21367726pubmed:affiliationOxford Vaccine Group, University of Oxford, Oxford, UK. rajeka.lazarus@doctors.net.uklld:pubmed
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