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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-8-8
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pubmed:abstractText |
High levels of tissue factor (TF) have been associated with atherosclerotic plaques. The specific pathways linked to TF expression in endothelial cells (ECs) have not been well defined. This study compared TF expression in human umbilical vein ECs (HUVECs) exposed to laminar shear stress (LSS) using a parallel flow chamber and to orbital shear stress (OSS) using an orbital shaker. We also compared the effects of thrombin (TH) stimulation of ECs exposed to different shear forces on the expression of TF and investigated the role that second messengers, p38 and extracellular signal-regulated kinase 1 and 2 (ERK1/2), had in the EC response.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1097-6809
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
480-8
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pubmed:meshHeading |
pubmed-meshheading:21367569-Analysis of Variance,
pubmed-meshheading:21367569-Blotting, Western,
pubmed-meshheading:21367569-Cell Culture Techniques,
pubmed-meshheading:21367569-Cells, Cultured,
pubmed-meshheading:21367569-Endothelial Cells,
pubmed-meshheading:21367569-Enzyme Activation,
pubmed-meshheading:21367569-Humans,
pubmed-meshheading:21367569-Mechanotransduction, Cellular,
pubmed-meshheading:21367569-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:21367569-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:21367569-Phosphorylation,
pubmed-meshheading:21367569-Protein Kinase Inhibitors,
pubmed-meshheading:21367569-RNA, Messenger,
pubmed-meshheading:21367569-Stress, Mechanical,
pubmed-meshheading:21367569-Thrombin,
pubmed-meshheading:21367569-Thromboplastin,
pubmed-meshheading:21367569-Time Factors,
pubmed-meshheading:21367569-Up-Regulation,
pubmed-meshheading:21367569-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2011
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pubmed:articleTitle |
Laminar shear, but not orbital shear, has a synergistic effect with thrombin stimulation on tissue factor expression in human umbilical vein endothelial cells.
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pubmed:affiliation |
Department of Vascular Surgery, Yale University School of Medicine, New Haven, CT, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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