Linked Life Data

21367515

Source:http://linkedlifedata.com/resource/pubmed/id/21367515

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2011-4-18
pubmed:abstractText
The runt-domain transcription factor Runx3 plays crucial roles during development such as regulating gene expression. It has been shown that Runx3 is involved in neurogenesis, thymopoiesis and functions like a tumor suppressor. Runx3 null mouse die soon after birth as a result of multiple organ defects. Runx3 null mouse lung shows an abnormal phenotype and loss of Runx3 induced remodeling in the lung. Interestingly, lung adenocarcinoma is observed in Runx3 heterozygous mice at 18 months of age. During lung development various cellular and molecular events occur such as cell proliferation, cell death, differentiation and epithelial-mesenchymal transition (EMT). To understand the specific lethal events in Runx3 null mice, we examined cellular and molecular networks involved in EMT, and EMT inducers were quantified by RT-qPCR during lung development. Excessive EMT was observed in lungs at PN1 day in Runx3 null mice and PN18 months in Runx3 heterozygous mice. Pharmacologic inhibition of EMT was used to curb tumor progression. In this study, U0126 was injected to pregnant mouse for inhibition of pERK signaling. After U0126 treatment, life spans of newborn mice were increased and lung hyperplasia was partially rescued by down-regulated cell proliferation and EMT. Our data suggest that Runx3 is involved in crucial regulation of alveolar differentiation and tumor suppression in developing mouse lung.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1432-0436
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
81
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
261-8
pubmed:meshHeading
pubmed-meshheading:21367515-Adenocarcinoma, pubmed-meshheading:21367515-Animals, pubmed-meshheading:21367515-Butadienes, pubmed-meshheading:21367515-Cell Differentiation, pubmed-meshheading:21367515-Cell Transformation, Neoplastic, pubmed-meshheading:21367515-Core Binding Factor Alpha 3 Subunit, pubmed-meshheading:21367515-Epithelial-Mesenchymal Transition, pubmed-meshheading:21367515-Female, pubmed-meshheading:21367515-Gene Expression Regulation, Developmental, pubmed-meshheading:21367515-Lung, pubmed-meshheading:21367515-Lung Neoplasms, pubmed-meshheading:21367515-Mice, pubmed-meshheading:21367515-Mice, Knockout, pubmed-meshheading:21367515-Nitriles, pubmed-meshheading:21367515-Pregnancy, pubmed-meshheading:21367515-Pulmonary Alveoli, pubmed-meshheading:21367515-Signal Transduction, pubmed-meshheading:21367515-eIF-2 Kinase
pubmed:year
2011
pubmed:articleTitle
Runx3 is a crucial regulator of alveolar differentiation and lung tumorigenesis in mice.
pubmed:affiliation
Division in Anatomy and Developmental Biology, Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Brain Korea 21 project, Oral Science Research Center, College of Dentistry, Yonsei Center of Biotechnology, Yonsei University, Seoul, Republic of Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't