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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1990-1-22
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pubmed:abstractText |
To investigate the role of vpr (viral protein R) in the replication and cytopathicity of human immunodeficiency virus type 1 (HIV-1), infectious proviruses were constructed that were isogenic except for the ability to produce the protein product of vpr. The experiments described here demonstrate that vpr encodes a 96 amino acid 15 kDa protein. The vpr product increases the rate of replication and accelerates the cytopathic effect of the virus in T cells. Vpr acts in trans to increase levels of viral protein expression. The stimulatory effect of vpr is observed to act on the HIV-1 LTR as well as on several heterologous promoters.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0894-9255
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2136707-Cytopathogenic Effect, Viral,
pubmed-meshheading:2136707-Gene Products, vpr,
pubmed-meshheading:2136707-HIV-1,
pubmed-meshheading:2136707-Proviruses,
pubmed-meshheading:2136707-Retroviridae Proteins,
pubmed-meshheading:2136707-Trans-Activators,
pubmed-meshheading:2136707-Viral Regulatory and Accessory Proteins,
pubmed-meshheading:2136707-Virus Replication,
pubmed-meshheading:2136707-vpr Gene Products, Human Immunodeficiency Virus
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pubmed:year |
1990
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pubmed:articleTitle |
Identification of HIV-1 vpr product and function.
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pubmed:affiliation |
Department of Human Retrovirology, Dana-Farber Cancer Institute, Harvard Medical School, Massachusetts 02115.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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