Linked Life Data

21366870

Source:http://linkedlifedata.com/resource/pubmed/id/21366870

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2011-3-3
pubmed:abstractText
Maternal mental health (MMH) problems are a major public health concern with adverse consequences for women, their offspring and families. Intake of long-chain polyunsaturated fatty acids, especially the n-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid, which are found predominantly in cold water fish, has been associated with a range of mental health outcomes and may improve MMH. The demands for these fatty acids are increased during pregnancy and lactation, and may influence MMH as they are integral parts of cell membranes especially in the brain and play a role in physiological processes such as membrane fluidity and neurotransmitter function. Observational studies and intervention trials that have examined the role of fatty acids and MMH disorders especially post-partum depression (PPD) were identified using Pubmed and have been reviewed. Only three well-designed large prospective studies were identified; these studies examined the relationship between dietary intakes of n-3 fatty acids and fish during pregnancy, and found limited evidence of an association with PPD. Several intervention trials (n=8) have been done but generally suffer from small sample size and vary in terms of the study subject characteristics and timing, duration and dosage of the intervention. The results are mixed, but one recently completed large trial found no evidence of benefit among women who received DHA during pregnancy. Few studies have been conducted in developing countries, and gaps remain on the influence of other nutrient deficiencies, genetic polymorphisms that influence n-3 fatty acid synthesis and total fatty acid intake.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1740-8709
pubmed:author
pubmed:copyrightInfo
© 2011 Blackwell Publishing Ltd.
pubmed:issnType
Electronic
pubmed:volume
7 Suppl 2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
99-111
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Fatty acid status and maternal mental health.
pubmed:affiliation
Hubert Department of Global Health, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30332, USA. uramakr@sph.emory.edu
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural