Linked Life Data

2136560

Source:http://linkedlifedata.com/resource/pubmed/id/2136560

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1992-10-7
pubmed:abstractText
Pilocarpine-induced status epilepticus leads to widespread limbic forebrain damage in rats and provides a model for studying intractable epilepsy. Noradrenergic neurons in suspension, prepared from the locus coeruleus region of donors on the 13th or 14th gestational day, were microinjected bilaterally into the hippocampus (8 rats) and into the cerebellum (4 rats) or the olfactory bulb (4 rats) of epileptic rats. Three microliters of suspension was deposited at the rate of 1 microliter/min. Control animals were not submitted to surgery (4 rats). After six weeks a marked reduction of suppression of spontaneous seizures was observed in intrahippocampally grafted rats. From these preliminary results we suggest that grafts can be used to suppress spontaneous recurrent epileptic seizures.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0100-879X
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1267-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Some evidence that intrahippocampal grafting of noradrenergic neurons suppresses spontaneous seizures in epileptic rats.
pubmed:affiliation
Disciplina de Neurologia Experimental, Escola Paulista de Medicina, São Paulo, Brasil.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't