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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-3-2
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pubmed:abstractText |
We analyzed prospectively whether MGMT (O(6)-methylguanine-DNA methyltransferase) mRNA expression gains prognostic/predictive impact independent of MGMT promoter methylation in malignant glioma patients undergoing radiotherapy with concomitant and adjuvant temozolomide or temozolomide alone. As DNA-methyltransferases (DNMTs) are the enzymes responsible for setting up and maintaining DNA methylation patterns in eukaryotic cells, we analyzed further, whether MGMT promoter methylation is associated with upregulation of DNMT expression.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21365007-10325416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21365007-11070098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21365007-12101420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21365007-14555514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21365007-15455350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21365007-15719030,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/21365007-15977639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21365007-16453286,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/21365007-18580490,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/21365007-2358840
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e17156
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pubmed:meshHeading |
pubmed-meshheading:21365007-Adult,
pubmed-meshheading:21365007-Aged,
pubmed-meshheading:21365007-Aged, 80 and over,
pubmed-meshheading:21365007-Antineoplastic Agents, Alkylating,
pubmed-meshheading:21365007-Brain Neoplasms,
pubmed-meshheading:21365007-Chemotherapy, Adjuvant,
pubmed-meshheading:21365007-DNA Methylation,
pubmed-meshheading:21365007-Dacarbazine,
pubmed-meshheading:21365007-Drug Resistance, Neoplasm,
pubmed-meshheading:21365007-Female,
pubmed-meshheading:21365007-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21365007-Glioma,
pubmed-meshheading:21365007-Humans,
pubmed-meshheading:21365007-Male,
pubmed-meshheading:21365007-Middle Aged,
pubmed-meshheading:21365007-O(6)-Methylguanine-DNA Methyltransferase,
pubmed-meshheading:21365007-Prognosis,
pubmed-meshheading:21365007-Promoter Regions, Genetic,
pubmed-meshheading:21365007-RNA, Messenger,
pubmed-meshheading:21365007-Radiotherapy, Adjuvant,
pubmed-meshheading:21365007-Treatment Outcome
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pubmed:year |
2011
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pubmed:articleTitle |
O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation.
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pubmed:affiliation |
Department of Anaesthesiology, Ludwig Maximilians University, Munich, Germany. fkreth@med.uni-muenchen.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Validation Studies
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