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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-3-2
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pubmed:abstractText |
Telomere shortening is a cell-intrinsic mechanism that limits cell proliferation by induction of DNA damage responses resulting either in apoptosis or cellular senescence. Shortening of telomeres has been shown to occur during human aging and in chronic diseases that accelerate cell turnover, such as chronic hepatitis. Telomere shortening can limit organ homeostasis and regeneration in response to injury. Whether the same holds true for pancreas regeneration in response to injury is not known.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21364961-10089885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21364961-10404142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21364961-10591218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21364961-10678830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21364961-12087054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21364961-12881434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21364961-1333985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21364961-15492508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21364961-1601022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21364961-1613801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21364961-16860503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21364961-17143283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21364961-17392301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21364961-17433324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21364961-17466744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21364961-18497539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21364961-2199965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21364961-2436216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21364961-3438304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21364961-7102934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21364961-9041259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21364961-9242615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21364961-9560153
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e17122
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pubmed:meshHeading |
pubmed-meshheading:21364961-Animals,
pubmed-meshheading:21364961-Cell Aging,
pubmed-meshheading:21364961-Cell Division,
pubmed-meshheading:21364961-DNA Damage,
pubmed-meshheading:21364961-Mice,
pubmed-meshheading:21364961-Mice, Knockout,
pubmed-meshheading:21364961-Pancreas, Exocrine,
pubmed-meshheading:21364961-RNA,
pubmed-meshheading:21364961-Regeneration,
pubmed-meshheading:21364961-Telomerase,
pubmed-meshheading:21364961-Telomere,
pubmed-meshheading:21364961-Time Factors,
pubmed-meshheading:21364961-Tumor Suppressor Protein p53
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pubmed:year |
2011
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pubmed:articleTitle |
Regeneration of the exocrine pancreas is delayed in telomere-dysfunctional mice.
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pubmed:affiliation |
Institute of Molecular Medicine and Max-Planck-Research-Group on Stem Cell Aging, University of Ulm, Ulm, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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