rdf:type |
|
lifeskim:mentions |
umls-concept:C0007131,
umls-concept:C0027651,
umls-concept:C0035696,
umls-concept:C0040649,
umls-concept:C0205210,
umls-concept:C0596611,
umls-concept:C0871261,
umls-concept:C1512523,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1707520,
umls-concept:C2604307,
umls-concept:C2911692
|
pubmed:issue |
1
|
pubmed:dateCreated |
2011-3-2
|
pubmed:abstractText |
Molecular targeted drugs is now widely used in non-small cell lung cancer (NSCLC) clinical treatment. Icotinib hydrochloride is a new type of oral epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKIs). In this study, we examined the role of EGFR, K-RAS, B-RAF somatic mutations and EGFR mRNA expression in tumor specimens from advanced NSCLC patients as predicators of the efficacy of icotinib hydrochloride.
|
pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/BRAF protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Crown Ethers,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins B-raf,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins p21(ras),
http://linkedlifedata.com/resource/pubmed/chemical/Quinazolines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/icotinib
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0366-6999
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
124
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
19-25
|
pubmed:meshHeading |
pubmed-meshheading:21362302-Adult,
pubmed-meshheading:21362302-Aged,
pubmed-meshheading:21362302-Antineoplastic Agents,
pubmed-meshheading:21362302-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:21362302-Crown Ethers,
pubmed-meshheading:21362302-Exons,
pubmed-meshheading:21362302-Female,
pubmed-meshheading:21362302-Humans,
pubmed-meshheading:21362302-Male,
pubmed-meshheading:21362302-Middle Aged,
pubmed-meshheading:21362302-Mutation,
pubmed-meshheading:21362302-Proto-Oncogene Proteins B-raf,
pubmed-meshheading:21362302-Proto-Oncogene Proteins p21(ras),
pubmed-meshheading:21362302-Quinazolines,
pubmed-meshheading:21362302-RNA, Messenger,
pubmed-meshheading:21362302-Receptor, Epidermal Growth Factor
|
pubmed:year |
2011
|
pubmed:articleTitle |
Tumor gene mutations and messenger RNA expression: correlation with clinical response to icotinib hydrochloride in non-small cell lung cancer.
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pubmed:affiliation |
Department of Respiration, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China.
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pubmed:publicationType |
Journal Article
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