| pubmed-article:21361910 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21361910 | lifeskim:mentions | umls-concept:C0007452 | lld:lifeskim |
| pubmed-article:21361910 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:21361910 | lifeskim:mentions | umls-concept:C0004358 | lld:lifeskim |
| pubmed-article:21361910 | lifeskim:mentions | umls-concept:C0026138 | lld:lifeskim |
| pubmed-article:21361910 | lifeskim:mentions | umls-concept:C1384511 | lld:lifeskim |
| pubmed-article:21361910 | lifeskim:mentions | umls-concept:C1510827 | lld:lifeskim |
| pubmed-article:21361910 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:21361910 | pubmed:dateCreated | 2011-3-11 | lld:pubmed |
| pubmed-article:21361910 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21361910 | pubmed:abstractText | Insulin autoantibodies (IAA) can appear in children within months of introducing solid foods to the diet and before clinical type 1 diabetes. The aim of this study was to determine whether infant dietary antigens could be immunizing agents of IAA. To this end, IAA binding to [(125) I]insulin was competed with food preparations and extracts of foods encountered in the infant diet (milk formulas, bovine milk, wheat flour, fowl meal). Bovine milk powder extracts inhibited IAA-positive samples from six of 53 children (age 0·3-14·0 years) participating in German prospective cohorts. Inhibition in these sera ranged from 23 to 100%. Competition was abolished when hydrolyzed milk powder was used. Competition with protein components of bovine milk found that two of the six milk-reactive sera were inhibited strongly by alpha- and beta-casein; none were inhibited by the milk proteins bovine serum albumin or lactoglobulins. The two casein-reactive sera had high affinity to alpha-casein (1·7×10(9) ; 3·1×10(9) ?l/mol), and lesser affinity to beta-casein (4·0×10(8) ; 7·0×10(7) ?l/mol) and insulin (2·6×10(8) ; 1·6×10(8) ?l/mol). No children with milk-reactive IAA developed autoantibodies to other islet autoantigens or diabetes (median follow-up 9·8 years). These results suggest that autoimmunity to insulin can occur infrequently via cross-reactivity to food proteins, but this form of IAA immunization does not appear to be associated with progression to diabetes. | lld:pubmed |
| pubmed-article:21361910 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21361910 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21361910 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21361910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21361910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21361910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21361910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21361910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21361910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21361910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21361910 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21361910 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:21361910 | pubmed:issn | 1365-2249 | lld:pubmed |
| pubmed-article:21361910 | pubmed:author | pubmed-author:KrauseSS | lld:pubmed |
| pubmed-article:21361910 | pubmed:author | pubmed-author:AdlerKK | lld:pubmed |
| pubmed-article:21361910 | pubmed:author | pubmed-author:BonifacioEE | lld:pubmed |
| pubmed-article:21361910 | pubmed:author | pubmed-author:ZieglerA GAG | lld:pubmed |
| pubmed-article:21361910 | pubmed:author | pubmed-author:MuellerD BDB | lld:pubmed |
| pubmed-article:21361910 | pubmed:author | pubmed-author:AchenbachPP | lld:pubmed |
| pubmed-article:21361910 | pubmed:author | pubmed-author:HeningerA-KAK | lld:pubmed |
| pubmed-article:21361910 | pubmed:copyrightInfo | © 2011 The Authors. Clinical and Experimental Immunology © 2011 British Society for Immunology. | lld:pubmed |
| pubmed-article:21361910 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21361910 | pubmed:volume | 164 | lld:pubmed |
| pubmed-article:21361910 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21361910 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21361910 | pubmed:pagination | 42-9 | lld:pubmed |
| pubmed-article:21361910 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:21361910 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21361910 | pubmed:articleTitle | Insulin autoantibodies with high affinity to the bovine milk protein alpha casein. | lld:pubmed |
| pubmed-article:21361910 | pubmed:affiliation | Diabetes Research Institute, Forschergruppe Diabetes e.V., Munich Center for Regenerative Therapies - Dresden, Dresden University of Technology, Dresden, Germany. | lld:pubmed |
| pubmed-article:21361910 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21361910 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21361910 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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