Source:http://linkedlifedata.com/resource/pubmed/id/21361910
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2011-3-11
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| pubmed:databankReference | |
| pubmed:abstractText |
Insulin autoantibodies (IAA) can appear in children within months of introducing solid foods to the diet and before clinical type 1 diabetes. The aim of this study was to determine whether infant dietary antigens could be immunizing agents of IAA. To this end, IAA binding to [(125) I]insulin was competed with food preparations and extracts of foods encountered in the infant diet (milk formulas, bovine milk, wheat flour, fowl meal). Bovine milk powder extracts inhibited IAA-positive samples from six of 53 children (age 0·3-14·0 years) participating in German prospective cohorts. Inhibition in these sera ranged from 23 to 100%. Competition was abolished when hydrolyzed milk powder was used. Competition with protein components of bovine milk found that two of the six milk-reactive sera were inhibited strongly by alpha- and beta-casein; none were inhibited by the milk proteins bovine serum albumin or lactoglobulins. The two casein-reactive sera had high affinity to alpha-casein (1·7×10(9) ; 3·1×10(9) ?l/mol), and lesser affinity to beta-casein (4·0×10(8) ; 7·0×10(7) ?l/mol) and insulin (2·6×10(8) ; 1·6×10(8) ?l/mol). No children with milk-reactive IAA developed autoantibodies to other islet autoantigens or diabetes (median follow-up 9·8 years). These results suggest that autoimmunity to insulin can occur infrequently via cross-reactivity to food proteins, but this form of IAA immunization does not appear to be associated with progression to diabetes.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Caseins,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Iodine Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Milk Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Serum Albumin, Bovine
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| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
1365-2249
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| pubmed:author | |
| pubmed:copyrightInfo |
© 2011 The Authors. Clinical and Experimental Immunology © 2011 British Society for Immunology.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
164
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
42-9
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:21361910-Adolescent,
pubmed-meshheading:21361910-Animals,
pubmed-meshheading:21361910-Autoantibodies,
pubmed-meshheading:21361910-Binding, Competitive,
pubmed-meshheading:21361910-CD4-Positive T-Lymphocytes,
pubmed-meshheading:21361910-Caseins,
pubmed-meshheading:21361910-Cattle,
pubmed-meshheading:21361910-Cell Proliferation,
pubmed-meshheading:21361910-Child,
pubmed-meshheading:21361910-Child, Preschool,
pubmed-meshheading:21361910-Diabetes Mellitus, Type 1,
pubmed-meshheading:21361910-Flow Cytometry,
pubmed-meshheading:21361910-Humans,
pubmed-meshheading:21361910-Infant,
pubmed-meshheading:21361910-Infant Food,
pubmed-meshheading:21361910-Insulin,
pubmed-meshheading:21361910-Insulin Antibodies,
pubmed-meshheading:21361910-Iodine Radioisotopes,
pubmed-meshheading:21361910-Milk Proteins,
pubmed-meshheading:21361910-Protein Binding,
pubmed-meshheading:21361910-Serum Albumin, Bovine
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| pubmed:year |
2011
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| pubmed:articleTitle |
Insulin autoantibodies with high affinity to the bovine milk protein alpha casein.
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| pubmed:affiliation |
Diabetes Research Institute, Forschergruppe Diabetes e.V., Munich Center for Regenerative Therapies - Dresden, Dresden University of Technology, Dresden, Germany.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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