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pubmed-article:21360524pubmed:abstractTextRadical surgery is the de facto treatment for early rectal cancer. Conservative surgery with transanal endoscopic microsurgery can achieve high rates of cure but the histopathological measures of outcome used to select local treatment lack precision. Biomarkers associated with disease progression, particularly mesorectal nodal metastasis, are urgently required. The aim was to compare patterns of gene-specific hypermethylation in radically excised rectal cancers with histopathological stage.lld:pubmed
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pubmed-article:21360524pubmed:authorpubmed-author:JonesC ECElld:pubmed
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pubmed-article:21360524pubmed:authorpubmed-author:LeongK JKJlld:pubmed
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pubmed-article:21360524pubmed:copyrightInfoCopyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.lld:pubmed
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pubmed-article:21360524pubmed:volume98lld:pubmed
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pubmed-article:21360524pubmed:articleTitleMethylation profiling of rectal cancer identifies novel markers of early-stage disease.lld:pubmed
pubmed-article:21360524pubmed:affiliationSchool of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. kjleong@gmail.comlld:pubmed
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pubmed-article:21360524pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed