rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
5
|
pubmed:dateCreated |
2011-4-4
|
pubmed:abstractText |
Radical surgery is the de facto treatment for early rectal cancer. Conservative surgery with transanal endoscopic microsurgery can achieve high rates of cure but the histopathological measures of outcome used to select local treatment lack precision. Biomarkers associated with disease progression, particularly mesorectal nodal metastasis, are urgently required. The aim was to compare patterns of gene-specific hypermethylation in radically excised rectal cancers with histopathological stage.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
1365-2168
|
pubmed:author |
|
pubmed:copyrightInfo |
Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
|
pubmed:issnType |
Electronic
|
pubmed:volume |
98
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
724-34
|
pubmed:meshHeading |
pubmed-meshheading:21360524-Adenocarcinoma,
pubmed-meshheading:21360524-Adult,
pubmed-meshheading:21360524-Aged,
pubmed-meshheading:21360524-Aged, 80 and over,
pubmed-meshheading:21360524-DNA Methylation,
pubmed-meshheading:21360524-Early Detection of Cancer,
pubmed-meshheading:21360524-Female,
pubmed-meshheading:21360524-Genes, Tumor Suppressor,
pubmed-meshheading:21360524-Genetic Markers,
pubmed-meshheading:21360524-Humans,
pubmed-meshheading:21360524-Male,
pubmed-meshheading:21360524-Middle Aged,
pubmed-meshheading:21360524-Neoplasm Metastasis,
pubmed-meshheading:21360524-Rectal Neoplasms,
pubmed-meshheading:21360524-Sequence Analysis, DNA,
pubmed-meshheading:21360524-Tumor Markers, Biological
|
pubmed:year |
2011
|
pubmed:articleTitle |
Methylation profiling of rectal cancer identifies novel markers of early-stage disease.
|
pubmed:affiliation |
School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. kjleong@gmail.com
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|