rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
2011-3-11
|
pubmed:abstractText |
Several reports suggest diffusion of anticancer agents from bone cement may suppress tumor growth. New drug delivery systems have been developed that incorporate anticancer drugs into calcium phosphate cement (CPC) to maintain high concentrations of anticancer drugs at local sites. We investigated whether CPC implants containing anticancer drugs and caffeine, which enhance the cytocidal effect of anticancer drugs, would enhance their antitumor effects on rat osteosarcomas (SOSN2 cells).
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
1436-2023
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
16
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
77-84
|
pubmed:meshHeading |
pubmed-meshheading:21360005-Animals,
pubmed-meshheading:21360005-Antineoplastic Agents,
pubmed-meshheading:21360005-Bone Cements,
pubmed-meshheading:21360005-Bone Neoplasms,
pubmed-meshheading:21360005-Caffeine,
pubmed-meshheading:21360005-Calcium Phosphates,
pubmed-meshheading:21360005-Coated Materials, Biocompatible,
pubmed-meshheading:21360005-Disease Progression,
pubmed-meshheading:21360005-Drug Combinations,
pubmed-meshheading:21360005-Drug Synergism,
pubmed-meshheading:21360005-Follow-Up Studies,
pubmed-meshheading:21360005-Male,
pubmed-meshheading:21360005-Neoplasms, Experimental,
pubmed-meshheading:21360005-Osteosarcoma,
pubmed-meshheading:21360005-Rats,
pubmed-meshheading:21360005-Rats, Inbred F344,
pubmed-meshheading:21360005-Treatment Outcome
|
pubmed:year |
2011
|
pubmed:articleTitle |
Potentiation of the antitumor effect of calcium phosphate cement containing anticancer drug and caffeine on rat osteosarcoma.
|
pubmed:affiliation |
Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
|
pubmed:publicationType |
Journal Article,
Comparative Study
|