rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-3-1
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pubmed:abstractText |
Metallothionein 3 (MT-3) has been shown to protect against apoptotic neuronal death in the brains of patients with Alzheimer's disease. Zinc is a potent inhibitor of caspase-3 and its deficiency was found to promote apoptosis. Here, we measured the zinc and copper content in the brains of senescence-accelerated mouse/PRONE8 (SAMP8) and sought to investigate the effect of MT-3 on the apoptosis of neurons in the hippocampal CA1 region of these mice.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bax protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Copper,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Metallothionein,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Zinc,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-2-Associated X Protein,
http://linkedlifedata.com/resource/pubmed/chemical/growth inhibitory factor
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1678-4227
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
105-11
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pubmed:meshHeading |
pubmed-meshheading:21359432-Aging,
pubmed-meshheading:21359432-Animals,
pubmed-meshheading:21359432-Apoptosis,
pubmed-meshheading:21359432-Brain Chemistry,
pubmed-meshheading:21359432-Caspase 3,
pubmed-meshheading:21359432-Copper,
pubmed-meshheading:21359432-Growth Inhibitors,
pubmed-meshheading:21359432-Hippocampus,
pubmed-meshheading:21359432-Male,
pubmed-meshheading:21359432-Metallothionein,
pubmed-meshheading:21359432-Mice,
pubmed-meshheading:21359432-Nerve Tissue Proteins,
pubmed-meshheading:21359432-Neurons,
pubmed-meshheading:21359432-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:21359432-Species Specificity,
pubmed-meshheading:21359432-Zinc,
pubmed-meshheading:21359432-bcl-2-Associated X Protein
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pubmed:year |
2011
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pubmed:articleTitle |
Metallothionein 3 attenuated the apoptosis of neurons in the CA1 region of the hippocampus in the senescence-accelerated mouse/PRONE8 (SAMP8).
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pubmed:affiliation |
Department of Neurology, Shantou Central Hospital, Sun Yat-sen University, Guangdong, China.
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pubmed:publicationType |
Journal Article
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