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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-3-1
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pubmed:abstractText |
The growing number of novel candidate molecules for the treatment of allergic diseases imposed a dramatic increase in the demand for animal experiments to select immunogenic vaccines, a pre-requisite for efficacy. Because no in vitro methods to predict the immunogenicity of a protein are currently available, we developed an in vitro assay that exploits the link between a protein's immunogenicity and its susceptibility to endolysosomal proteolysis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21359181-11934876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21359181-12148782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21359181-12154002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21359181-12391225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21359181-12776207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21359181-12865072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21359181-1378066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21359181-14634090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21359181-15761154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21359181-15772168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21359181-16301657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21359181-16893568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21359181-16908625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21359181-17070909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21359181-17204652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21359181-17458170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21359181-17489234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21359181-17624416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21359181-17889932,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/21359181-18957408,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/21359181-20132976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21359181-20164435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21359181-20192803,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/21359181-8627171
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
pubmed-author:BohleBarbaraB,
pubmed-author:BrizaPeterP,
pubmed-author:EggerMatthiasM,
pubmed-author:FerreiraFátimaF,
pubmed-author:HainzlStefanS,
pubmed-author:HuberChristian GCG,
pubmed-author:JüretsAlexanderA,
pubmed-author:KitzmüllerClaudiaC,
pubmed-author:PichlerUlrikeU,
pubmed-author:RuzekSilkeS,
pubmed-author:WallnerMichaelM
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e17278
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pubmed:meshHeading |
pubmed-meshheading:21359181-Animals,
pubmed-meshheading:21359181-Antibody Formation,
pubmed-meshheading:21359181-Bone Marrow Cells,
pubmed-meshheading:21359181-Cell Line,
pubmed-meshheading:21359181-Dendritic Cells,
pubmed-meshheading:21359181-Genes, p53,
pubmed-meshheading:21359181-Humans,
pubmed-meshheading:21359181-Lysosomes,
pubmed-meshheading:21359181-Mice,
pubmed-meshheading:21359181-Mice, Inbred BALB C,
pubmed-meshheading:21359181-Mice, Inbred C57BL,
pubmed-meshheading:21359181-Mice, Knockout,
pubmed-meshheading:21359181-Protein Processing, Post-Translational,
pubmed-meshheading:21359181-Proteins,
pubmed-meshheading:21359181-Vaccines
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pubmed:year |
2011
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pubmed:articleTitle |
Assessing protein immunogenicity with a dendritic cell line-derived endolysosomal degradome.
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pubmed:affiliation |
Christian Doppler Laboratory for Allergy Diagnosis and Therapy, Department of Molecular Biology, University of Salzburg, Salzburg, Austria. matthias.egger@sbg.ac.at
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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