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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2011-3-15
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pubmed:databankReference |
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pubmed:abstractText |
In the Ongoing Telmisartan Alone and in Combination With Ramipril Global End Point Trial (ONTARGET), dual therapy did not reduce cardiovascular or renal outcomes compared with either angiotensin-converting enzyme inhibitors or angiotensin receptor blockers alone. Previous controlled trials with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers have demonstrated greater cardiovascular and renal benefit in people with renal risk. We hypothesized that dual therapy would be more effective than monotherapy in patients with low glomerular filtration rate and elevated albuminuria.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
123
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1098-107
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pubmed:meshHeading |
pubmed-meshheading:21357827-Aged,
pubmed-meshheading:21357827-Albuminuria,
pubmed-meshheading:21357827-Angiotensin Receptor Antagonists,
pubmed-meshheading:21357827-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:21357827-Benzimidazoles,
pubmed-meshheading:21357827-Benzoates,
pubmed-meshheading:21357827-Creatinine,
pubmed-meshheading:21357827-Drug Therapy, Combination,
pubmed-meshheading:21357827-Female,
pubmed-meshheading:21357827-Glomerular Filtration Rate,
pubmed-meshheading:21357827-Heart Failure,
pubmed-meshheading:21357827-Heart Rate,
pubmed-meshheading:21357827-Humans,
pubmed-meshheading:21357827-Kidney Failure, Chronic,
pubmed-meshheading:21357827-Male,
pubmed-meshheading:21357827-Middle Aged,
pubmed-meshheading:21357827-Myocardial Infarction,
pubmed-meshheading:21357827-Ramipril,
pubmed-meshheading:21357827-Stroke,
pubmed-meshheading:21357827-Treatment Outcome
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pubmed:year |
2011
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pubmed:articleTitle |
Cardiovascular and renal outcomes with telmisartan, ramipril, or both in people at high renal risk: results from the ONTARGET and TRANSCEND studies.
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pubmed:affiliation |
Division of Nephrology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada. sheldon.tobe@sunnybrook.ca
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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