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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2011-4-29
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pubmed:abstractText |
Methicillin-resistant Staphylococcus aureus with a MIC of linezolid of 4 ?g/ml, isolated from a patient who had undergone unsuccessful linezolid therapy, yielded linezolid-resistant mutants in blood agar at 48 h of incubation. The resistant clones showed a MIC of linezolid ranging from 8 to 64 ?g/ml and accumulated the T2500A mutation(s) of the rRNA genes. Emergence of these resistant clones appears to be facilitated by a cryptic mutation or mutations associated with chloramphenicol resistance.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1098-6596
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pubmed:author |
pubmed-author:FukuchiKunihikoK,
pubmed-author:HanakiHideakiH,
pubmed-author:HondaJunichiJ,
pubmed-author:Ikeda-DantsujiYurikaY,
pubmed-author:KakuMitsuoM,
pubmed-author:KohnoShigeruS,
pubmed-author:MikamoHiroshigeH,
pubmed-author:NakaeTaijiT,
pubmed-author:NikiYoshihitoY,
pubmed-author:TakesueYoshioY,
pubmed-author:TomonoKazunoriK,
pubmed-author:YanagiharaKatsunoriK
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pubmed:issnType |
Electronic
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2466-8
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pubmed:dateRevised |
2011-11-1
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pubmed:meshHeading |
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pubmed:year |
2011
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pubmed:articleTitle |
Emergence of linezolid-resistant mutants in a susceptible-cell population of methicillin-resistant Staphylococcus aureus.
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pubmed:affiliation |
Laboratory for Antimicrobial Agents, Kitasato University, 5-9-1 Shirokane, Minato-Ku, Tokyo 108-8641, Japan.
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pubmed:publicationType |
Journal Article
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