Source:http://linkedlifedata.com/resource/pubmed/id/21356386
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2011-3-1
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| pubmed:abstractText |
Cyclooxygenase-2 (COX-2) has been associated with cell growth regulation, tissue remodeling, and carcinogenesis. Ectopic expression of COX-2 in hepatocytes constitutes a nonphysiological condition ideal for evaluating the role of prostaglandins (PGs) in liver pathogenesis. The effect of COX-2-dependent PGs in chronic liver disease, hepatitis, fibrosis, and chemical hepatocarcinogenesis, has been investigated in transgenic (Tg) mice that express human COX-2 in hepatocytes and in Tg hepatic human cell lines. We have used three different complementary approaches: i) diethylnitrosamine (DEN)-induced chemical hepatocarcinogenesis in COX-2 Tg mice, ii) DEN/phenobarbital treatment of human COX-2 Tg hepatocyte-like cells, and iii) COX-2 Tg hepatocyte-like cells implants in nude mice. The data suggest that PGs produced by COX-2 in hepatocytes promoted mild hepatitis in 60-week-old mice, as assessed by histological examination, but failed to contribute to the development of liver fibrogenesis after methionine- and choline-deficient diet treatment. Moreover, liver injury, collagen content, and hepatic stellate cell activation were equally severe in wild-type and COX-2 Tg mice. The contribution of COX-2-dependent PGs to the development of DEN-induced hepatocarcinogenesis was evaluated in Tg mice, Tg hepatocyte-like cells, and nude mice and the analysis revealed that COX-2 expression favors the development of preneoplastic foci without affecting malignant transformation. Endogenous COX-2 expression in wild-type mice is a late event in the development of hepatocellular carcinoma.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin E,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Diethylnitrosamine,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-myc
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
1525-2191
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
178
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1361-73
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| pubmed:meshHeading |
pubmed-meshheading:21356386-Aging,
pubmed-meshheading:21356386-Animals,
pubmed-meshheading:21356386-Body Weight,
pubmed-meshheading:21356386-Cell Proliferation,
pubmed-meshheading:21356386-Cell Transformation, Neoplastic,
pubmed-meshheading:21356386-Cyclin E,
pubmed-meshheading:21356386-Cyclooxygenase 2,
pubmed-meshheading:21356386-Diethylnitrosamine,
pubmed-meshheading:21356386-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21356386-Hepatitis,
pubmed-meshheading:21356386-Hepatocytes,
pubmed-meshheading:21356386-Humans,
pubmed-meshheading:21356386-Liver,
pubmed-meshheading:21356386-Liver Cirrhosis,
pubmed-meshheading:21356386-Liver Neoplasms,
pubmed-meshheading:21356386-Mice,
pubmed-meshheading:21356386-Mice, Nude,
pubmed-meshheading:21356386-Mice, Transgenic,
pubmed-meshheading:21356386-Organ Size,
pubmed-meshheading:21356386-Precancerous Conditions,
pubmed-meshheading:21356386-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:21356386-Transgenes,
pubmed-meshheading:21356386-Xenograft Model Antitumor Assays
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| pubmed:year |
2011
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| pubmed:articleTitle |
Transgenic mice expressing cyclooxygenase-2 in hepatocytes reveal a minor contribution of this enzyme to chemical hepatocarcinogenesis.
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| pubmed:affiliation |
Institute of Biomedical Research Alberto Sols (CSIC-UAM), Madrid, Spain.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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