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pubmed-article:21355074pubmed:abstractTextWe previously reported that nelfinavir (NFV) induces G(1) cell-cycle block and apoptosis selectively in liposarcoma cell lines due to increased SREBP-1 (sterol regulatory element binding protein-1) expression in the absence of increased transcription. We postulate that NFV interferes with regulated intramembrane proteolysis of SREBP-1 and ATF6 (activating transcription factor 6).lld:pubmed
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pubmed-article:21355074pubmed:articleTitleNelfinavir induces liposarcoma apoptosis through inhibition of regulated intramembrane proteolysis of SREBP-1 and ATF6.lld:pubmed
pubmed-article:21355074pubmed:affiliationDepartment of Molecular Pharmacology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA.lld:pubmed
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