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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2011-4-4
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pubmed:abstractText |
We previously reported that nelfinavir (NFV) induces G(1) cell-cycle block and apoptosis selectively in liposarcoma cell lines due to increased SREBP-1 (sterol regulatory element binding protein-1) expression in the absence of increased transcription. We postulate that NFV interferes with regulated intramembrane proteolysis of SREBP-1 and ATF6 (activating transcription factor 6).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1,10-phenanthroline,
http://linkedlifedata.com/resource/pubmed/chemical/3,4-dichloroisocoumarin,
http://linkedlifedata.com/resource/pubmed/chemical/ATF6 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Activating Transcription Factor 6,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 6,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 9,
http://linkedlifedata.com/resource/pubmed/chemical/Coumarins,
http://linkedlifedata.com/resource/pubmed/chemical/FASN protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acid Synthetase Complex...,
http://linkedlifedata.com/resource/pubmed/chemical/MBTPS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Metalloendopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Nelfinavir,
http://linkedlifedata.com/resource/pubmed/chemical/Phenanthrolines,
http://linkedlifedata.com/resource/pubmed/chemical/Proprotein Convertases,
http://linkedlifedata.com/resource/pubmed/chemical/Protease Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SREBF1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Serine Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Sterol Regulatory Element Binding...,
http://linkedlifedata.com/resource/pubmed/chemical/hydroxy-t-butylamidenelfinavir,
http://linkedlifedata.com/resource/pubmed/chemical/membrane-bound transcription...
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1796-806
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pubmed:meshHeading |
pubmed-meshheading:21355074-Activating Transcription Factor 6,
pubmed-meshheading:21355074-Animals,
pubmed-meshheading:21355074-Antineoplastic Agents,
pubmed-meshheading:21355074-Apoptosis,
pubmed-meshheading:21355074-Caspase 6,
pubmed-meshheading:21355074-Caspase 9,
pubmed-meshheading:21355074-Cell Line, Tumor,
pubmed-meshheading:21355074-Cell Nucleus,
pubmed-meshheading:21355074-Cell Proliferation,
pubmed-meshheading:21355074-Cell Survival,
pubmed-meshheading:21355074-Coumarins,
pubmed-meshheading:21355074-Endoplasmic Reticulum,
pubmed-meshheading:21355074-Enzyme Activation,
pubmed-meshheading:21355074-Fatty Acid Synthetase Complex, Type I,
pubmed-meshheading:21355074-Female,
pubmed-meshheading:21355074-Humans,
pubmed-meshheading:21355074-Liposarcoma,
pubmed-meshheading:21355074-Metalloendopeptidases,
pubmed-meshheading:21355074-Mice,
pubmed-meshheading:21355074-Mice, SCID,
pubmed-meshheading:21355074-Nelfinavir,
pubmed-meshheading:21355074-Neoplasm Transplantation,
pubmed-meshheading:21355074-Phenanthrolines,
pubmed-meshheading:21355074-Proprotein Convertases,
pubmed-meshheading:21355074-Protease Inhibitors,
pubmed-meshheading:21355074-Protein Transport,
pubmed-meshheading:21355074-RNA, Small Interfering,
pubmed-meshheading:21355074-RNA Interference,
pubmed-meshheading:21355074-Recombinant Fusion Proteins,
pubmed-meshheading:21355074-Serine Endopeptidases,
pubmed-meshheading:21355074-Sterol Regulatory Element Binding Protein 1,
pubmed-meshheading:21355074-Transcription, Genetic,
pubmed-meshheading:21355074-Transplantation, Heterologous,
pubmed-meshheading:21355074-Tumor Burden
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pubmed:year |
2011
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pubmed:articleTitle |
Nelfinavir induces liposarcoma apoptosis through inhibition of regulated intramembrane proteolysis of SREBP-1 and ATF6.
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pubmed:affiliation |
Department of Molecular Pharmacology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA.
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pubmed:publicationType |
Journal Article
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