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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2011-4-18
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pubmed:abstractText |
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), causes 9 million new cases worldwide and 2 million deaths annually. Genetic linkage and association analyses have suggested several chromosomal regions and candidate genes involved in TB susceptibility. This study examines the association of TB disease susceptibility with a selection of biologically relevant genes on regions on chromosomes 7 (IL6 and CARD11) and 20 (CTSZ and MC3R) and fine mapping of the chromosome 7p22-p21 region identified through our genome scan. We analyzed 565 individuals from Kampala, Uganda, who were previously included in our genome-wide linkage scan. Association analyses were conducted for 1,417 single-nucleotide polymorphisms (SNP) that passed quality control. None of the candidate gene or fine mapping SNPs was significantly associated with TB susceptibility (p > 0.10). When we restricted the analysis to HIV-negative individuals, 2 SNPs on chromosome 7 were significantly associated with TB susceptibility (p < 0.05). Haplotype analyses identified a significant risk haplotype in cathepsin X (CTSZ; p = 0.0281, odds ratio = 1.5493, 95% confidence interval [1.039, 2.320]).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CARD Signaling Adaptor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CARD11 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cathepsin Z,
http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/MC3R protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Melanocortin, Type 3
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1879-1166
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pubmed:author |
pubmed-author:AdamsMark DMD,
pubmed-author:BakerAllison RAR,
pubmed-author:BoomW HenryWH,
pubmed-author:IgoRobert PRPJr,
pubmed-author:MaloneLaShaunda LLL,
pubmed-author:Mayanja-KizzaHarrietH,
pubmed-author:NserekoMaryM,
pubmed-author:QiuFeiyouF,
pubmed-author:SteinCatherine MCM,
pubmed-author:SupelakPamelaP,
pubmed-author:ZalwangoSarahS
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pubmed:copyrightInfo |
Copyright © 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
426-30
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:21354459-Adolescent,
pubmed-meshheading:21354459-Adult,
pubmed-meshheading:21354459-Aged,
pubmed-meshheading:21354459-CARD Signaling Adaptor Proteins,
pubmed-meshheading:21354459-Cathepsin Z,
pubmed-meshheading:21354459-Child,
pubmed-meshheading:21354459-Child, Preschool,
pubmed-meshheading:21354459-Female,
pubmed-meshheading:21354459-Genetic Predisposition to Disease,
pubmed-meshheading:21354459-Genome-Wide Association Study,
pubmed-meshheading:21354459-Guanylate Cyclase,
pubmed-meshheading:21354459-Haplotypes,
pubmed-meshheading:21354459-Humans,
pubmed-meshheading:21354459-Infant,
pubmed-meshheading:21354459-Interleukin-6,
pubmed-meshheading:21354459-Male,
pubmed-meshheading:21354459-Middle Aged,
pubmed-meshheading:21354459-Mycobacterium tuberculosis,
pubmed-meshheading:21354459-Polymorphism, Single Nucleotide,
pubmed-meshheading:21354459-Receptor, Melanocortin, Type 3,
pubmed-meshheading:21354459-Tuberculosis, Pulmonary,
pubmed-meshheading:21354459-Uganda
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pubmed:year |
2011
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pubmed:articleTitle |
Genetic susceptibility to tuberculosis associated with cathepsin Z haplotype in a Ugandan household contact study.
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pubmed:affiliation |
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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