Linked Life Data

21353793

Source:http://linkedlifedata.com/resource/pubmed/id/21353793

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2011-4-4
pubmed:abstractText
The uterine endometrium is exquisitely sensitive to steroid hormones that act through well-described nuclear receptors. Estrogen drives epithelial proliferation, and progesterone inhibits growth and causes cell differentiation. The importance of progesterone as a key inhibitor of carcinogenesis is reflected by the observation that women who ovulate and produce progesterone almost never get endometrial cancer. In this review we describe seminal research findings that define progesterone as the major endometrial tumor suppressor. We discuss the genes and diverse signaling pathways that are controlled by progesterone through progesterone receptors (PRs) and also the multiple factors that regulate progesterone/PR activity. By defining these progesterone-regulated factors and pathways we identify the principal therapeutic opportunities to control the growth of endometrial cancer.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1879-3061
pubmed:author
pubmed:copyrightInfo
Copyright © 2011. Published by Elsevier Ltd.
pubmed:issnType
Electronic
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
145-52
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Progesterone: the ultimate endometrial tumor suppressor.
pubmed:affiliation
Department of Obstetrics & Gynecology and Holden Comprehensive Cancer Center,The University of Iowa, Iowa City, Iowa 52242, USA.
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural