|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2011-5-25
|
|
pubmed:abstractText |
Although the combination of doxorubicin (Dox) and trastuzumab (Trz) reduces breast cancer progression and recurrence, it is limited by significant cardiotoxic side effects. Little is known about the utility of antioxidants in the prevention of this drug-induced cardiomyopathy. The aim of the study was to determine whether the antioxidant probucol (Prob) would be useful in attenuating Dox and Trz-mediated cardiotoxicity.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anthracyclines,
http://linkedlifedata.com/resource/pubmed/chemical/Antibiotics, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal, Humanized,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Probucol,
http://linkedlifedata.com/resource/pubmed/chemical/trastuzumab
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1097-6795
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright © 2011 American Society of Echocardiography. Published by Mosby, Inc. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
24
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
699-705
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:21353471-Analysis of Variance,
pubmed-meshheading:21353471-Animals,
pubmed-meshheading:21353471-Anthracyclines,
pubmed-meshheading:21353471-Antibiotics, Antineoplastic,
pubmed-meshheading:21353471-Antibodies, Monoclonal,
pubmed-meshheading:21353471-Antibodies, Monoclonal, Humanized,
pubmed-meshheading:21353471-Antineoplastic Agents,
pubmed-meshheading:21353471-Antioxidants,
pubmed-meshheading:21353471-Blotting, Western,
pubmed-meshheading:21353471-Breast Neoplasms,
pubmed-meshheading:21353471-Cardiomyopathies,
pubmed-meshheading:21353471-Echocardiography, Doppler,
pubmed-meshheading:21353471-Female,
pubmed-meshheading:21353471-Mice,
pubmed-meshheading:21353471-Probucol,
pubmed-meshheading:21353471-Random Allocation,
pubmed-meshheading:21353471-Survival Rate
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
The cardioprotective role of probucol against anthracycline and trastuzumab-mediated cardiotoxicity.
|
|
pubmed:affiliation |
Institute of Cardiovascular Sciences, St. Boniface Research Centre, University of Manitoba, 409 Tache Avenue, Winnipeg, Manitoba, Canada.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
