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pubmed-article:21353315pubmed:dateCreated2011-4-11lld:pubmed
pubmed-article:21353315pubmed:abstractTextWe investigated the overlap shared between the immunoglobulin (Ig) proteome of the cerebrospinal fluid (CSF) and the B cell Ig-transcriptome of CSF and the central nervous system (CNS) tissue of three patients with multiple sclerosis. We determined the IgG-proteomes of CSF by mass spectrometry, and compared them to the IgG-transcriptomes from CSF and brain lesions, which were analyzed by cDNA cloning. Characteristic peptides that were identified in the CSF-proteome could also be detected in the transcriptomes of both, brain lesions and CSF, providing evidence for a strong overlap of the IgG repertoires in brain lesions and in the CSF.lld:pubmed
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pubmed-article:21353315pubmed:authorpubmed-author:BrückWolfgang...lld:pubmed
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pubmed-article:21353315pubmed:authorpubmed-author:HohlfeldReinh...lld:pubmed
pubmed-article:21353315pubmed:authorpubmed-author:LottspeichFri...lld:pubmed
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pubmed-article:21353315pubmed:authorpubmed-author:MenteleReinha...lld:pubmed
pubmed-article:21353315pubmed:authorpubmed-author:DornmairKlaus...lld:pubmed
pubmed-article:21353315pubmed:authorpubmed-author:O'ConnorKevin...lld:pubmed
pubmed-article:21353315pubmed:authorpubmed-author:LovatoLauraLlld:pubmed
pubmed-article:21353315pubmed:authorpubmed-author:WillisSimon...lld:pubmed
pubmed-article:21353315pubmed:authorpubmed-author:TurkKatherine...lld:pubmed
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pubmed-article:21353315pubmed:authorpubmed-author:ForneIgnasiIlld:pubmed
pubmed-article:21353315pubmed:copyrightInfoCopyright © 2011 Elsevier B.V. All rights reserved.lld:pubmed
pubmed-article:21353315pubmed:issnTypeElectroniclld:pubmed
pubmed-article:21353315pubmed:volume233lld:pubmed
pubmed-article:21353315pubmed:ownerNLMlld:pubmed
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pubmed-article:21353315pubmed:pagination245-8lld:pubmed
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pubmed-article:21353315pubmed:year2011lld:pubmed
pubmed-article:21353315pubmed:articleTitleRelated B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin.lld:pubmed
pubmed-article:21353315pubmed:affiliationInstitute of Clinical Neuroimmunology, Ludwig Maximilians University, 81377 Munich, Germany.lld:pubmed
pubmed-article:21353315pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21353315pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:21353315pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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