|
rdf:type |
|
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lifeskim:mentions |
umls-concept:C0004561,
umls-concept:C0007806,
umls-concept:C0009013,
umls-concept:C0021027,
umls-concept:C0026769,
umls-concept:C0030705,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C0927232,
umls-concept:C1552599,
umls-concept:C1704787
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pubmed:issue |
1-2
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|
pubmed:dateCreated |
2011-4-11
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pubmed:abstractText |
We investigated the overlap shared between the immunoglobulin (Ig) proteome of the cerebrospinal fluid (CSF) and the B cell Ig-transcriptome of CSF and the central nervous system (CNS) tissue of three patients with multiple sclerosis. We determined the IgG-proteomes of CSF by mass spectrometry, and compared them to the IgG-transcriptomes from CSF and brain lesions, which were analyzed by cDNA cloning. Characteristic peptides that were identified in the CSF-proteome could also be detected in the transcriptomes of both, brain lesions and CSF, providing evidence for a strong overlap of the IgG repertoires in brain lesions and in the CSF.
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pubmed:grant |
|
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
1872-8421
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|
pubmed:author |
pubmed-author:BrückWolfgangW,
pubmed-author:DornmairKlausK,
pubmed-author:ForneIgnasiI,
pubmed-author:HaflerDavid ADA,
pubmed-author:HohlfeldReinhardR,
pubmed-author:ImhofAxelA,
pubmed-author:LottspeichFriedrichF,
pubmed-author:LovatoLauraL,
pubmed-author:MenteleReinhardR,
pubmed-author:O'ConnorKevin CKC,
pubmed-author:ObermeierBirgitB,
pubmed-author:TurkKatherine WKW,
pubmed-author:WekerleHartmutH,
pubmed-author:WillisSimon NSN
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier B.V. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
233
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
245-8
|
|
pubmed:meshHeading |
|
|
pubmed:year |
2011
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|
pubmed:articleTitle |
Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin.
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|
pubmed:affiliation |
Institute of Clinical Neuroimmunology, Ludwig Maximilians University, 81377 Munich, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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