Source:http://linkedlifedata.com/resource/pubmed/id/21352929
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2011-5-2
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| pubmed:abstractText |
In patients with central visual field scotomata a large part of visual cortex is not adequately stimulated. Over time this lack of input could lead to a reduction of gray matter in the affected cortical areas. We used Voxel Based Morphometry to investigate structural brain changes in patients with central scotomata due to hereditary retinal dystrophies and compared their results to those of normal sighted subjects. Additionally we correlated clinical and demographic characteristics like duration of disease, scotoma size, visual acuity, fixation stability and reading speed to the amount of gray matter in whole brain analyses within the patient group. We found a decrease in gray matter around the lesion projection zone in visual cortex of patients in comparison to controls. Gray matter loss along the posterior and middle portions of the calcarine sulcus is also correlated with scotoma size, indicating that indeed the lack of functional input provokes the gray matter alterations. In whole brain regression analyses within the patient group we found an additional cluster in the right superior and middle frontal gyri, slightly anterior to the frontal eye fields, where gray matter correlated positively with fixation stability. This could be regarded as a consequence of oculomotor learning.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
1095-9572
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:day |
1
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| pubmed:volume |
56
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1556-65
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| pubmed:meshHeading |
pubmed-meshheading:21352929-Adolescent,
pubmed-meshheading:21352929-Adult,
pubmed-meshheading:21352929-Aged,
pubmed-meshheading:21352929-Behavior,
pubmed-meshheading:21352929-Child,
pubmed-meshheading:21352929-Female,
pubmed-meshheading:21352929-Fixation, Ocular,
pubmed-meshheading:21352929-Humans,
pubmed-meshheading:21352929-Image Processing, Computer-Assisted,
pubmed-meshheading:21352929-Linear Models,
pubmed-meshheading:21352929-Magnetic Resonance Imaging,
pubmed-meshheading:21352929-Male,
pubmed-meshheading:21352929-Middle Aged,
pubmed-meshheading:21352929-Reading,
pubmed-meshheading:21352929-Regression Analysis,
pubmed-meshheading:21352929-Retinal Dystrophies,
pubmed-meshheading:21352929-Scotoma,
pubmed-meshheading:21352929-Visual Acuity,
pubmed-meshheading:21352929-Visual Cortex,
pubmed-meshheading:21352929-Visual Fields,
pubmed-meshheading:21352929-Young Adult
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| pubmed:year |
2011
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| pubmed:articleTitle |
Gray matter alterations in visual cortex of patients with loss of central vision due to hereditary retinal dystrophies.
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| pubmed:affiliation |
Institute of Psychology, University of Regensburg, Regensburg, Germany. tina.plank@psychologie.uni-regensburg.de
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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