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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-2-25
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pubmed:abstractText |
In the arms race of host-microbe co-evolution, successful microbial pathogens have evolved ingenious ways to evade host immune responses. In this Review, we focus on 'crosstalk manipulation' - the microbial strategies that instigate, subvert or disrupt the molecular signalling crosstalk between receptors of the innate immune system. This proactive interference undermines host defences and contributes to microbial adaptive fitness and persistent infections. Understanding how pathogens exploit host receptor crosstalk mechanisms and infiltrate the host signalling network is essential for developing interventions to redirect the host response and achieve protective immunity.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/AI30040,
http://linkedlifedata.com/resource/pubmed/grant/AI68730,
http://linkedlifedata.com/resource/pubmed/grant/AI72106,
http://linkedlifedata.com/resource/pubmed/grant/CA112162,
http://linkedlifedata.com/resource/pubmed/grant/DE015254,
http://linkedlifedata.com/resource/pubmed/grant/DE017138,
http://linkedlifedata.com/resource/pubmed/grant/DE018292,
http://linkedlifedata.com/resource/pubmed/grant/DE021580,
http://linkedlifedata.com/resource/pubmed/grant/EB3968,
http://linkedlifedata.com/resource/pubmed/grant/GM62134,
http://linkedlifedata.com/resource/pubmed/grant/P01 AI068730-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 AI030040-15,
http://linkedlifedata.com/resource/pubmed/grant/R01 AI072106-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA112162-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 DE015254-09,
http://linkedlifedata.com/resource/pubmed/grant/R01 DE017138-07,
http://linkedlifedata.com/resource/pubmed/grant/R01 DE018292-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 EB003968-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 GM062134-08,
http://linkedlifedata.com/resource/pubmed/grant/RC4 DE021580-01
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1474-1741
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
187-200
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pubmed:dateRevised |
2011-5-9
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pubmed:meshHeading |
pubmed-meshheading:21350579-Amino Acid Motifs,
pubmed-meshheading:21350579-Animals,
pubmed-meshheading:21350579-Bacteria,
pubmed-meshheading:21350579-Candida albicans,
pubmed-meshheading:21350579-Host-Pathogen Interactions,
pubmed-meshheading:21350579-Humans,
pubmed-meshheading:21350579-Immunity, Innate,
pubmed-meshheading:21350579-Mice,
pubmed-meshheading:21350579-Models, Immunological,
pubmed-meshheading:21350579-Molecular Mimicry,
pubmed-meshheading:21350579-Receptor Cross-Talk,
pubmed-meshheading:21350579-Receptors, Pattern Recognition,
pubmed-meshheading:21350579-Signal Transduction,
pubmed-meshheading:21350579-Toll-Like Receptors,
pubmed-meshheading:21350579-Viruses
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pubmed:year |
2011
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pubmed:articleTitle |
Microbial manipulation of receptor crosstalk in innate immunity.
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pubmed:affiliation |
University of Louisville, Department of Microbiology and Immunology, Louisville, Kentucky 40292, USA. g0haji01@louisville.edu
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pubmed:publicationType |
Journal Article,
Review,
Research Support, N.I.H., Extramural
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