|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0024432,
umls-concept:C0031308,
umls-concept:C0086418,
umls-concept:C0166418,
umls-concept:C0441655,
umls-concept:C0860920,
umls-concept:C0870432,
umls-concept:C1523987,
umls-concept:C1555465,
umls-concept:C1704259,
umls-concept:C1705417,
umls-concept:C1705987,
umls-concept:C1832073,
umls-concept:C2936350
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|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2011-4-15
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|
pubmed:abstractText |
A crucial step in atherogenesis is the infiltration of the subendothelial space of large arteries by monocytes where they differentiate into macrophages and transform into lipid-loaded foam cells. Macrophages are heterogeneous cells that adapt their response to environmental cytokines. Th1 cytokines promote monocyte differentiation into M1 macrophages, whereas Th2 cytokines trigger an "alternative" M2 phenotype.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
1524-4571
|
|
pubmed:author |
pubmed-author:BaronMorganeM,
pubmed-author:BoriesGaelG,
pubmed-author:BouhlelMohamed AmineMA,
pubmed-author:Chinetti-GbaguidiGiuliaG,
pubmed-author:CopinCorinneC,
pubmed-author:DerudasBrunoB,
pubmed-author:HaulonStephaneS,
pubmed-author:JudeBrigitteB,
pubmed-author:MayiThérèseT,
pubmed-author:SebtiYasmineY,
pubmed-author:StaelsBartB,
pubmed-author:TailleuxAnneA,
pubmed-author:VanhoutteJonathanJ,
pubmed-author:ZawadzkiChristopheC
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
15
|
|
pubmed:volume |
108
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
985-95
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|
pubmed:meshHeading |
pubmed-meshheading:21350215-Cell Differentiation,
pubmed-meshheading:21350215-Cells, Cultured,
pubmed-meshheading:21350215-Cholesterol,
pubmed-meshheading:21350215-Genetic Predisposition to Disease,
pubmed-meshheading:21350215-Humans,
pubmed-meshheading:21350215-Leukocytes, Mononuclear,
pubmed-meshheading:21350215-Macrophages,
pubmed-meshheading:21350215-Orphan Nuclear Receptors,
pubmed-meshheading:21350215-PPAR gamma,
pubmed-meshheading:21350215-Phagocytosis,
pubmed-meshheading:21350215-Plaque, Atherosclerotic
|
|
pubmed:year |
2011
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|
pubmed:articleTitle |
Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPAR? and LXR? pathways.
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pubmed:affiliation |
Univ Lille Nord de France, Lille, France.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
