Linked Life Data

21349986

Source:http://linkedlifedata.com/resource/pubmed/id/21349986

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 8
pubmed:dateCreated
2011-7-14
pubmed:abstractText
Clostridial glucosylating toxins are the main virulence factors of clostridia responsible for gangrene and/or colitis. These toxins have been well characterized to inactivate Rho/Ras-GTPases through glucosylation. However, the signalling pathways downstream of Rho/Ras-GTPases leading to the intracellular effects of these toxins are only partially known. Rac-dependent modification of focal adhesion complexes and phosphoinositide metabolism seem to be key processes involved in actin filament depolymerization and disorganization of intercellular junctions. In addition, clostridial glucosylating toxins induce Rho/Ras-independent intracellular effects such as activation of mitogen-activated protein kinase pathways, which are used by some of these toxins to trigger an inflammatory response.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1473-5644
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1057-69
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Rho/Ras-GTPase-dependent and -independent activity of clostridial glucosylating toxins.
pubmed:affiliation
Institut Pasteur, Unité des Bactéries Anaérobies et Toxines, 25 rue du Dr Roux, 75724 Paris cedex 15, France. mpopoff@pasteur.fr
pubmed:publicationType
Journal Article, Review