Linked Life Data

2134966

Source:http://linkedlifedata.com/resource/pubmed/id/2134966

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-5-14
pubmed:abstractText
Biological effects of such metals as nickel and chromium alloys used as dental materials, particularly their metabolism and potential toxicity have not been well elucidated. Certain metallic materials are known to be toxic and arsenic, nickel, chromium and lead have been shown to have carcinogenic potential in laboratory animals. This study was performed to assess carcinogenicity and accumulation in tissues of metals in rats. Three-week old male F344/NSle rats were injected s. c. with 30 mg/kg of nickel acetate or 60 mg/kg of lead acetate weekly for 5 weeks after 2 weeks of acclimatization, and were followed by observation for 80 weeks. The group treated with lead acetate showed a greater incidence of tumor, compared with the nickel acetate-treated group. Teeth, femora, other bones and neoplastic tissue from tumor-bearing animals were subjected to elemental analysis by spectrophotometry and ICP. High concentrations of Pb were detected in the mandibula, femur and tumor tissue of rats with Pb-induced tumor. In rats with Ni-induced tumor, Ni was not demonstrable in the mandibula, maxilla or tumor tissue and detected in small quantities in the nasal bone and femur. Thus, Pb proved to be retained in tissue at the site of injection and also markedly accumulated in the tooth and femur as assessed 46 weeks after injections; whereas Ni was no longer detectable in tissue at the injection site, nor in tumor tissue but only small quantities in the said bones.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0029-8484
pubmed:author
pubmed:issnType
Print
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
269-73
pubmed:dateRevised
2011-7-29
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Inorganic elements in the tooth and bone tissues of rats bearing nickel acetate- and lead acetate-induced tumors.
pubmed:affiliation
Department of Histology, Nippon Dental University School of Dentistry at Niigata.
pubmed:publicationType
Journal Article