Source:http://linkedlifedata.com/resource/pubmed/id/21348445
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2011-4-25
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pubmed:abstractText |
Bioassay-guided fractionation of extracts of the brown alga Sporochnus comosus led to the isolation of five new compounds, comosusols A-D (3-6) and comosone A (7). The structures of all isolated compounds were elucidated using standard one- and two-dimensional NMR techniques, as well as comparison with literature values. The cytotoxic activity of all compounds was investigated against a panel of human tumor and mammalian cell lines. These assays found eight of the nine compounds had GI(50) values in the 8-63 ?M range.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1520-6025
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:day |
25
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
739-43
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pubmed:meshHeading |
pubmed-meshheading:21348445-Antineoplastic Agents,
pubmed-meshheading:21348445-Australia,
pubmed-meshheading:21348445-Cyclohexanones,
pubmed-meshheading:21348445-Drug Screening Assays, Antitumor,
pubmed-meshheading:21348445-Humans,
pubmed-meshheading:21348445-Molecular Structure,
pubmed-meshheading:21348445-Nuclear Magnetic Resonance, Biomolecular,
pubmed-meshheading:21348445-Phaeophyta,
pubmed-meshheading:21348445-Phenols,
pubmed-meshheading:21348445-Quinones
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pubmed:year |
2011
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pubmed:articleTitle |
Comosusols A-D and comosone A: cytotoxic compounds from the brown alga Sporochnus comosus.
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pubmed:affiliation |
Australian Institute of Marine Science, PMB No. 3, Townsville MC, Townsville, 4810, Australia.
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pubmed:publicationType |
Journal Article
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