Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2011-3-22
pubmed:abstractText
Recent evidence suggests that genetic variants that confer susceptibility to myocardial infarction (MI) may differ between men and women or between individuals with or without conventional risk factors for MI. We previously showed that rs6929846 of BTN2A1 and rs2569512 of ILF3 were significantly associated with MI in Japanese individuals. In the present study, we examined the associations of rs6929846 of BTN2A1 or rs2569512 of ILF3 to MI among individuals stratified by the absence or presence of hypertension, diabetes mellitus (DM) and chronic kidney disease (CKD). The study population was comprised of 5689 unrelated Japanese individuals, including 1626 subjects with MI and 4063 controls with or without hypertension, DM or CKD. Multivariable logistic regression analyses with adjustment for covariates revealed that rs6929846 of BTN2A1 was significantly associated with MI in individuals with (P=0.0001; odds ratio, 1.49) or without (P=1.6x10-7; odds ratio, 2.32) hypertension; in individuals with (P=0.0002; odds ratio, 1.65) or without (P=8.1x10-7; odds ratio, 1.76) DM; and in individuals without CKD (P=6.0x10-11; odds ratio, 2.03), but not in those with CKD. Similar analyses revealed that rs2569512 of ILF3 was significantly associated with MI in individuals with (P=0.0041; odds ratio, 1.26) or without (P=0.0051; odds ratio, 1.78) hypertension; in individuals with (P=0.0200; odds ratio, 1.46) or without (P=0.0174; odds ratio, 1.43) DM; and in individuals with (P=0.0011, odds ratio, 1.47) or without (P=0.0237; odds ratio, 1.34) CKD. Results suggested that the association of rs6929846 in BTN2A1 with MI was more apparent in low-risk individuals than in high-risk individuals, whereas the association of rs2569512 in ILF3 with MI was not influenced by the absence or presence of hypertension, DM or CKD. Stratification of subjects based on hypertension, DM or CKD may thus be informative in order to achieve personalized prevention of MI with the use of genetic information.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1791-244X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
745-52
pubmed:meshHeading
pubmed-meshheading:21347509-Aged, pubmed-meshheading:21347509-Aged, 80 and over, pubmed-meshheading:21347509-Asian Continental Ancestry Group, pubmed-meshheading:21347509-Diabetes Complications, pubmed-meshheading:21347509-Female, pubmed-meshheading:21347509-Genetic Association Studies, pubmed-meshheading:21347509-Humans, pubmed-meshheading:21347509-Hypertension, pubmed-meshheading:21347509-Kidney Failure, Chronic, pubmed-meshheading:21347509-Logistic Models, pubmed-meshheading:21347509-Male, pubmed-meshheading:21347509-Middle Aged, pubmed-meshheading:21347509-Multivariate Analysis, pubmed-meshheading:21347509-Myocardial Infarction, pubmed-meshheading:21347509-Nuclear Factor 90 Proteins, pubmed-meshheading:21347509-Odds Ratio, pubmed-meshheading:21347509-Polymorphism, Single Nucleotide, pubmed-meshheading:21347509-Risk Factors
pubmed:year
2011
pubmed:articleTitle
Association of polymorphisms of BTN2A1 and ILF3 with myocardial infarction in Japanese individuals with or without hypertension, diabetes mellitus or chronic kidney disease.
pubmed:affiliation
Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't