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rdf:type |
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lifeskim:mentions |
umls-concept:C0007507,
umls-concept:C0010834,
umls-concept:C0015127,
umls-concept:C0019704,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0035687,
umls-concept:C0035696,
umls-concept:C0699759,
umls-concept:C0700364,
umls-concept:C1314792,
umls-concept:C1419997
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pubmed:issue |
1
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pubmed:dateCreated |
2011-3-28
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pubmed:abstractText |
We have previously shown that SRp55 inhibits splicing from HIV-1 exon 3, thereby generating partially spliced mRNAs encoding HIV-1 vpr. Here we show that SRp55 also inhibits splicing from HIV-1 exon 5 to generate HIV-1 vpu/env mRNA, albeit with lower efficiency. We also show that inhibition of HIV-1 splicing by SRp55 causes the appearance of partially spliced vpu, env and vpr mRNAs in the cytoplasm. SRp55 could also induce production of extracellular p24gag from a rev-defective HIV-1 provirus. These results indicate that SRp55 aids in the generation of partially spliced and unspliced HIV-1 mRNAs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Human Immunodeficiency Virus...,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/RNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SRSF6 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Regulatory and Accessory...,
http://linkedlifedata.com/resource/pubmed/chemical/env Gene Products, Human...,
http://linkedlifedata.com/resource/pubmed/chemical/rev Gene Products, Human...,
http://linkedlifedata.com/resource/pubmed/chemical/vpu protein, Human...
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1872-7492
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier B.V. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
157
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
82-91
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21345357-Cells, Cultured,
pubmed-meshheading:21345357-Cytoplasm,
pubmed-meshheading:21345357-Exons,
pubmed-meshheading:21345357-Genome, Viral,
pubmed-meshheading:21345357-HIV-1,
pubmed-meshheading:21345357-Human Immunodeficiency Virus Proteins,
pubmed-meshheading:21345357-Humans,
pubmed-meshheading:21345357-Nuclear Proteins,
pubmed-meshheading:21345357-Phosphoproteins,
pubmed-meshheading:21345357-Plasmids,
pubmed-meshheading:21345357-Proviruses,
pubmed-meshheading:21345357-RNA, Messenger,
pubmed-meshheading:21345357-RNA, Viral,
pubmed-meshheading:21345357-RNA Splicing,
pubmed-meshheading:21345357-RNA-Binding Proteins,
pubmed-meshheading:21345357-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21345357-Viral Regulatory and Accessory Proteins,
pubmed-meshheading:21345357-env Gene Products, Human Immunodeficiency Virus,
pubmed-meshheading:21345357-rev Gene Products, Human Immunodeficiency Virus
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pubmed:year |
2011
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pubmed:articleTitle |
Inhibition of splicing by serine-arginine rich protein 55 (SRp55) causes the appearance of partially spliced HIV-1 mRNAs in the cytoplasm.
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pubmed:affiliation |
Department of Medical Biochemistry & Microbiology, Uppsala University, BMC, 75123 Uppsala, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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