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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1992-4-30
|
| pubmed:abstractText |
How the cell maintains and uses its heritable information may be a critical factor in neoplasia. For example, neoplastic development is thought to depend upon the interplay between random genomic instability and nonrandom selective forces. Information theory provides a means to analyze these processes. One may quantitate not only the amount and lability of information contained within a segment of genetic code, but also the genotypic heterogeneity and the degree of selection affecting a population of cells. In addition, it is theoretically possible to monitor genetic information as it is processed by cells during replication, transcription, and translation. These parameters could permit a detailed analysis of the evolutionary changes hypothesized to underlie neoplastic development.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0025-5564
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
100
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
143-59
|
| pubmed:dateRevised |
2009-11-11
|
| pubmed:meshHeading | |
| pubmed:year |
1990
|
| pubmed:articleTitle |
The use of information theory to analyze genomic changes in neoplasia.
|
| pubmed:affiliation |
Department of Medicine, Princess Margaret Hospital, Toronto, Ontario, Canada.
|
| pubmed:publicationType |
Journal Article
|