Linked Life Data

21344643

Source:http://linkedlifedata.com/resource/pubmed/id/21344643

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2011-4-26
pubmed:abstractText
Several studies suggested a genetic component in the etiology of obsessive-compulsive disorder (OCD). COMT involves in the degradation of dopamine and norepinephrin. As another functional SNP locus, COMT -287A/G polymorphism showed an effect on enzyme activity, suggesting that it may influence brain dopamine levels. To identify association of COMT -287A/G polymorphism with susceptibility to OCD in Chinese Han population. We evaluate the genetic contribution of the COMT -287A/G polymorphism in 200 OCD patients and 403 OCD-free control of Chinese Han population by PCR-RFLP. In addition, we investigate whether COMT -287A/G polymorphism is associated with one or more of these symptom dimensions or other characteristics such as sex, age of onset, and tic-relatedness and evaluate the association of the factorial structure of OCD symptoms from the Y-BOCS checklist with the COMT -287A/G polymorphism. A statistical difference was found in the genotypic frequencies of COMT -287A/G between the OCD and control groups (?(2) ?=?13.99, DF?=?2, P?=?0.00091) and in the genotypic frequencies of GG genotype versus AA and AG genotypes of COMT -287 (?(2) ?=?13.49, DF?=?1, P?=?0.00024, OR?=?3.43, 95% CI?=?1.78-6.62). There was a trend for an association in the genotypic distributions of COMT -287A/G polymorphism of males (?(2) ?=?27.81; DF?=?2; P?<?0.001) and females (?(2) ?=?7.31; DF?=?2; P?=?0.026) between the OCD patients and the controls. Using principal component analysis, we derived 5 factors from 12 main contents of OCD symptoms from the Y-BOCS checklist and found no association with COMT -287A/G polymorphism. Our study supports the involvement of the COMT -287A/G polymorphism in the genetic susceptibility to OCD in Chinese Han population.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1552-485X
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Wiley-Liss, Inc.
pubmed:issnType
Electronic
pubmed:volume
156B
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
393-400
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Association of catechol-O-methyl transferase (COMT) gene -287A/G polymorphism with susceptibility to obsessive-compulsive disorder in Chinese Han population.
pubmed:affiliation
Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Medical College, Qingdao University, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't