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pubmed:abstractText |
The geometric mean 50% inhibitory concentration (IC50) for Proveblue, a methylene blue complying with the European Pharmacopoeia, was more active on 23 P. falciparum strains than chloroquine, quinine, mefloquine, monodesethylamodiaquine, and lumefantrine. We did not find significant associations between the Proveblue IC50 and polymorphisms in the pfcrt, pfmdr1, pfmdr2, pfmrp, and pfnhe-1 genes or the copy numbers of the pfmdr1 and pfmdr2 genes, all of which are involved in antimalarial resistance.
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pubmed:affiliation |
Unité de Parasitologie, Institut de Recherche Biomédicale des Armées-Antenne de Marseille, Allée du Médecin-Colonel Jamot, Parc le Pharo, BP 60109, 13262 Marseille Cedex 7, France.
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