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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
5
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pubmed:dateCreated |
2011-4-22
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pubmed:abstractText |
An increase in the expression of autoantigens and their presenting molecules human leukocyte antigen (HLA) class I has been demonstrated to be responsible for autoimmune diseases. Thyroid transcription factor-1 (TTF-1 or NKX2-1) synchronously upregulates both HLA class I and thyroid-specific autoantigen, which may be involved in the pathological process of autoimmune thyroiditis. In this study, the expressions and potential role of TTF-1 and HLA class I in Hashimoto's disease (HT) were examined.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1479-683X
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:volume |
164
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
795-800
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pubmed:meshHeading |
pubmed-meshheading:21343336-Adult,
pubmed-meshheading:21343336-Aged,
pubmed-meshheading:21343336-Autoantibodies,
pubmed-meshheading:21343336-Female,
pubmed-meshheading:21343336-HLA Antigens,
pubmed-meshheading:21343336-Hashimoto Disease,
pubmed-meshheading:21343336-Histocompatibility Antigens Class I,
pubmed-meshheading:21343336-Humans,
pubmed-meshheading:21343336-Male,
pubmed-meshheading:21343336-Middle Aged,
pubmed-meshheading:21343336-Nuclear Proteins,
pubmed-meshheading:21343336-Transcription Factors,
pubmed-meshheading:21343336-Up-Regulation
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pubmed:year |
2011
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pubmed:articleTitle |
Upregulation of thyroid transcription factor-1 and human leukocyte antigen class I in Hashimoto's disease providing a clinical evidence for possible triggering autoimmune reaction.
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pubmed:affiliation |
Second Affiliated Hospital of Fujian Medical University, Quanzhou, People's Republic of China.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
