| pubmed-article:21342606 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21342606 | lifeskim:mentions | umls-concept:C0021839 | lld:lifeskim |
| pubmed-article:21342606 | lifeskim:mentions | umls-concept:C0023810 | lld:lifeskim |
| pubmed-article:21342606 | lifeskim:mentions | umls-concept:C0449438 | lld:lifeskim |
| pubmed-article:21342606 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:21342606 | lifeskim:mentions | umls-concept:C1442080 | lld:lifeskim |
| pubmed-article:21342606 | lifeskim:mentions | umls-concept:C0805586 | lld:lifeskim |
| pubmed-article:21342606 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:21342606 | pubmed:dateCreated | 2011-7-13 | lld:pubmed |
| pubmed-article:21342606 | pubmed:abstractText | The present study determined whether ?-ketoglutarate (AKG) might affect the expression of AMP-activated protein kinase (AMPK) and energy status in the intestinal mucosa of piglets challenged with Escherichia coli lipopolysaccharide (LPS). A total of eighteen piglets (weaned at 21 d of age) were allocated to one of three treatments: (1) non-challenged (control); (2) LPS-challenged (LPS); (3) LPS+1 % AKG (LPS+AKG). Piglets in the control and LPS groups were fed a maize- and soyabean meal-based diet, and the LPS+AKG group was fed the basal diet supplemented with 1 % AKG. On days 10, 12, 14 and 16 of the trial, piglets in the LPS and LPS+AKG groups were challenged with LPS (80 ?g/kg body weight), whereas piglets in the control group received the same volume of sterile saline. Pigs were euthanised 24 h after the last administration of LPS or saline to obtain intestinal mucosae for biochemical analysis. Compared with the control group, LPS administration decreased (P < 0·05) the oxidation of AKG, oleic acid, glutamine and glucose in enterocytes, decreased concentrations of ATP in the duodenal and jejunal mucosae and decreased adenylate energy charge (AMP:ATP ratio) in the jejunal and ileal mucosae. Additionally, LPS treatment reduced (P < 0·05) mucosal concentrations of phosphorylated AMPK in the jejunum and ileum as well as acetyl-CoA carboxylase in all segments of the small intestine. The adverse effects of LPS were reversed by AKG. Collectively, these results indicate that dietary supplementation with 1 % AKG beneficially modulates the AMPK signalling pathway to improve energy status in the small intestine of LPS-challenged piglets. | lld:pubmed |
| pubmed-article:21342606 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21342606 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21342606 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21342606 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21342606 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21342606 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21342606 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21342606 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21342606 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21342606 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21342606 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21342606 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21342606 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21342606 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21342606 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:21342606 | pubmed:issn | 1475-2662 | lld:pubmed |
| pubmed-article:21342606 | pubmed:author | pubmed-author:FastM LML | lld:pubmed |
| pubmed-article:21342606 | pubmed:author | pubmed-author:HaleC WCW | lld:pubmed |
| pubmed-article:21342606 | pubmed:author | pubmed-author:WuGuoyaoG | lld:pubmed |
| pubmed-article:21342606 | pubmed:author | pubmed-author:LiuJianJ | lld:pubmed |
| pubmed-article:21342606 | pubmed:author | pubmed-author:WangLeiL | lld:pubmed |
| pubmed-article:21342606 | pubmed:author | pubmed-author:KangPingP | lld:pubmed |
| pubmed-article:21342606 | pubmed:author | pubmed-author:LiuYulanY | lld:pubmed |
| pubmed-article:21342606 | pubmed:author | pubmed-author:YinYulongY | lld:pubmed |
| pubmed-article:21342606 | pubmed:author | pubmed-author:HouYongqingY | lld:pubmed |
| pubmed-article:21342606 | pubmed:author | pubmed-author:ZhuHuilingH | lld:pubmed |
| pubmed-article:21342606 | pubmed:author | pubmed-author:DingBinyingB | lld:pubmed |
| pubmed-article:21342606 | pubmed:author | pubmed-author:LiYongtangY | lld:pubmed |
| pubmed-article:21342606 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21342606 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:21342606 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21342606 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21342606 | pubmed:pagination | 357-63 | lld:pubmed |
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| pubmed-article:21342606 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21342606 | pubmed:articleTitle | Effects of ?-ketoglutarate on energy status in the intestinal mucosa of weaned piglets chronically challenged with lipopolysaccharide. | lld:pubmed |
| pubmed-article:21342606 | pubmed:affiliation | Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, People's Republic of China. houyq777@yahoo.com.cn | lld:pubmed |
| pubmed-article:21342606 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21342606 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:21342606 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
