Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1992-4-13
|
pubmed:abstractText |
A double-blind placebo-controlled between-patient study was carried out to assess the effects of oxiracetam (CGP 21690E) on memory function in patients with epilepsy. During a 12-week period, either oxiracetam (800 mg t.i.d.) or placebo was given to 30 patients. Twenty-four of the patients had a partial epilepsy. Most patients were on monotherapy carbamazepine. Effect of oxiracetam on memory and related cognitive functions were assessed, using a computerized neuropsychological testing method, while concomitant electrophysiological changes were investigated with routine EEG registration, power spectrum analysis and auditory evoked event-related potentials (P300). Subjective evaluation of well-being was quantified with a mood rating scale. The results did not show any meaningful changes in memory function. This finding is in line with the subjective patient reports and the P300 measures.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0302-282X
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
24
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
90-101
|
pubmed:dateRevised |
2006-7-19
|
pubmed:meshHeading |
pubmed-meshheading:2134116-Adolescent,
pubmed-meshheading:2134116-Adult,
pubmed-meshheading:2134116-Affect,
pubmed-meshheading:2134116-Cognition,
pubmed-meshheading:2134116-Double-Blind Method,
pubmed-meshheading:2134116-Electroencephalography,
pubmed-meshheading:2134116-Epilepsy,
pubmed-meshheading:2134116-Evoked Potentials, Auditory,
pubmed-meshheading:2134116-Female,
pubmed-meshheading:2134116-Humans,
pubmed-meshheading:2134116-Male,
pubmed-meshheading:2134116-Memory Disorders,
pubmed-meshheading:2134116-Mental Processes,
pubmed-meshheading:2134116-Middle Aged,
pubmed-meshheading:2134116-Psychotropic Drugs,
pubmed-meshheading:2134116-Pyrrolidines
|
pubmed:articleTitle |
Double-blind placebo-controlled, neuropsychological and neurophysiological investigations with oxiracetam (CGP 21690E) in memory-impaired patients with epilepsy.
|
pubmed:affiliation |
Institute voor Epilepsiebestrijding; Meer & Bosch/De Cruquiushoeve, Heemstede, Nederland.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|