rdf:type |
|
lifeskim:mentions |
umls-concept:C0003234,
umls-concept:C0030705,
umls-concept:C0087111,
umls-concept:C0205195,
umls-concept:C0205390,
umls-concept:C0215136,
umls-concept:C0278488,
umls-concept:C0671970,
umls-concept:C1883567,
umls-concept:C2603343,
umls-concept:C2830183
|
pubmed:issue |
7
|
pubmed:dateCreated |
2011-4-5
|
pubmed:abstractText |
Most patients with metastatic breast cancer (MBC) progress after chemotherapy. Cabazitaxel (XRP6258) is a new taxoid that is active in chemotherapy-resistant tumour cell lines. The objectives of this phase I/II study were to assess the maximum tolerated dose (MTD), safety profile, pharmacokinetics, and activity of cabazitaxel plus capecitabine in patients with MBC who had been previously treated with taxanes and anthracyclines.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
1879-0852
|
pubmed:author |
|
pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ltd. All rights reserved.
|
pubmed:issnType |
Electronic
|
pubmed:volume |
47
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1037-45
|
pubmed:dateRevised |
2011-11-17
|
pubmed:meshHeading |
pubmed-meshheading:21339064-Adult,
pubmed-meshheading:21339064-Aged,
pubmed-meshheading:21339064-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:21339064-Area Under Curve,
pubmed-meshheading:21339064-Breast Neoplasms,
pubmed-meshheading:21339064-Deoxycytidine,
pubmed-meshheading:21339064-Drug Resistance, Neoplasm,
pubmed-meshheading:21339064-Female,
pubmed-meshheading:21339064-Fluorouracil,
pubmed-meshheading:21339064-Humans,
pubmed-meshheading:21339064-Maximum Tolerated Dose,
pubmed-meshheading:21339064-Middle Aged,
pubmed-meshheading:21339064-Neoplasm Metastasis,
pubmed-meshheading:21339064-Taxoids,
pubmed-meshheading:21339064-Treatment Outcome
|
pubmed:year |
2011
|
pubmed:articleTitle |
A multicentre dose-escalating study of cabazitaxel (XRP6258) in combination with capecitabine in patients with metastatic breast cancer progressing after anthracycline and taxane treatment: a phase I/II study.
|
pubmed:affiliation |
University Hôpital Jean Minjoz, Besançon, France.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Clinical Trial, Phase II,
Clinical Trial, Phase III
|