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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-3-22
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pubmed:abstractText |
Lymphoid cells that express the nuclear hormone receptor ROR?t are involved in containment of the large intestinal microbiota and defense against pathogens through the production of interleukin 17 (IL-17) and IL-22. They include adaptive IL-17-producing helper T cells (T(H)17 cells), as well as innate lymphoid cells (ILCs) such as lymphoid tissue-inducer (LTi) cells and IL-22-producing NKp46+ cells. Here we show that in contrast to T(H)17 cells, both types of ROR?t+ ILCs constitutively produced most of the intestinal IL-22 and that the symbiotic microbiota repressed this function through epithelial expression of IL-25. This function was greater in the absence of adaptive immunity and was fully restored and required after epithelial damage, which demonstrates a central role for ROR?t+ ILCs in intestinal homeostasis. Our data identify a finely tuned equilibrium among intestinal symbionts, adaptive immunity and ROR?t+ ILCs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Ly,
http://linkedlifedata.com/resource/pubmed/chemical/D17Wsu104e protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-17,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukins,
http://linkedlifedata.com/resource/pubmed/chemical/Natural Cytotoxicity Triggering...,
http://linkedlifedata.com/resource/pubmed/chemical/Ncr1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Subfamily 1...,
http://linkedlifedata.com/resource/pubmed/chemical/interleukin-22
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1529-2916
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
320-6
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pubmed:meshHeading |
pubmed-meshheading:21336274-Adaptive Immunity,
pubmed-meshheading:21336274-Animals,
pubmed-meshheading:21336274-Antigens, Ly,
pubmed-meshheading:21336274-Female,
pubmed-meshheading:21336274-Flow Cytometry,
pubmed-meshheading:21336274-Homeostasis,
pubmed-meshheading:21336274-Humans,
pubmed-meshheading:21336274-Interleukin-17,
pubmed-meshheading:21336274-Interleukins,
pubmed-meshheading:21336274-Intestines,
pubmed-meshheading:21336274-Lymphoid Tissue,
pubmed-meshheading:21336274-Male,
pubmed-meshheading:21336274-Mice,
pubmed-meshheading:21336274-Mice, Knockout,
pubmed-meshheading:21336274-Mice, Transgenic,
pubmed-meshheading:21336274-Natural Cytotoxicity Triggering Receptor 1,
pubmed-meshheading:21336274-Nuclear Receptor Subfamily 1, Group F, Member 3,
pubmed-meshheading:21336274-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21336274-Signal Transduction,
pubmed-meshheading:21336274-Symbiosis,
pubmed-meshheading:21336274-Time Factors
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pubmed:year |
2011
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pubmed:articleTitle |
ROR?t+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota.
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pubmed:affiliation |
Institut Pasteur, Lymphoid Tissue Development Unit, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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