Linked Life Data

21335280

Source:http://linkedlifedata.com/resource/pubmed/id/21335280

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2011-2-21
pubmed:abstractText
The process of angiogenesis is essential for tumor progression and metastasis; however, antiangiogenesis therapy-induced hypoxia and inflammation are perhaps the driving force for tumor escape and metastasis formation, thereby compromising its efficacy. This warrants the complete understanding of the molecular and cellular basis of antiangiogenesis therapy and necessitates the identification of potential signaling events in the host microenvironment, which are involved in tumor angiogenesis and metastasis, to improve the treatment of cancer. In this context, the zebrafish/tumor xenograft model represents an emerging vertebrate system to study the correlation between tumor angiogenesis, inflammation, and metastasis and to better understand the modification of tumor microenvironment by antiangiogenesis therapy. This review article describes the necessity to study the microenvironment of host-tumor interface by introducing basic concepts of angiogenesis, emerging paradigms, and challenges of antiangiogenesis therapy and provides an update on the importance of the zebrafish/tumor xenograft model to address these issues.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1873-2615
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
114-9
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Zebrafish model: worth considering in defining tumor angiogenesis.
pubmed:affiliation
Biomedical/Biotechnology Research Institute, North Carolina Central University, North Carolina Research Campus, Nutrition Research Center, Kannapolis, NC 28081, USA.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't