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pubmed-article:21334892pubmed:abstractTextThe pharmacokinetic based optimisation of a novel series of indole-2-carboxamide antagonists of the cannabinoid CB(1) receptor is disclosed. Compound 24 was found to be a highly potent and selective cannabinoid CB(1) antagonist with high predicted human oral bioavailability.lld:pubmed
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pubmed-article:21334892pubmed:copyrightInfoCopyright © 2011 Elsevier Ltd. All rights reserved.lld:pubmed
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pubmed-article:21334892pubmed:articleTitlePharmacokinetic optimisation of novel indole-2-carboxamide cannabinoid CB1 antagonists.lld:pubmed
pubmed-article:21334892pubmed:affiliationDepartment of Chemistry, MSD, Newhouse, Lanarkshire ML1 5SH, UK. phillip.cowley@tppgd.comlld:pubmed
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