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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2011-3-14
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pubmed:abstractText |
The pharmacokinetic based optimisation of a novel series of indole-2-carboxamide antagonists of the cannabinoid CB(1) receptor is disclosed. Compound 24 was found to be a highly potent and selective cannabinoid CB(1) antagonist with high predicted human oral bioavailability.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:BakerJamesJ,
pubmed-author:BuchananKirsteen IKI,
pubmed-author:CarlyleIanI,
pubmed-author:ClarkJohn KJK,
pubmed-author:ClarksonThomas RTR,
pubmed-author:CowleyPhillip MPM,
pubmed-author:DeehanMaureenM,
pubmed-author:EdwardsDarrenD,
pubmed-author:KiyoiYasukoY,
pubmed-author:MartinIainI,
pubmed-author:OsbournDawnD,
pubmed-author:WalkerGlennG,
pubmed-author:WardNickN,
pubmed-author:WishartGrantG
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2034-9
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pubmed:meshHeading |
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pubmed:year |
2011
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pubmed:articleTitle |
Pharmacokinetic optimisation of novel indole-2-carboxamide cannabinoid CB1 antagonists.
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pubmed:affiliation |
Department of Chemistry, MSD, Newhouse, Lanarkshire ML1 5SH, UK. phillip.cowley@tppgd.com
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pubmed:publicationType |
Journal Article
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