Linked Life Data

21334793

Source:http://linkedlifedata.com/resource/pubmed/id/21334793

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2011-3-4
pubmed:abstractText
Semi-synthetic analogues of ?-boswellic acid (BA) and 11-keto-?-boswellic acid (KBA) were comparatively evaluated for in vitro cytotoxicity against human myeloid leukaemia (HL-60) and human cervical carcinoma (HeLa) cells. 2-Cyano analogues of both the triterpenes were observed to have significant cytotoxicity against both the cells, displaying cytotoxicity in HL-60 cells at low concentrations. Further investigations suggested the proapoptotic potential associated with the two molecules to induce cytotoxicity in HL-60 cells, where one of them showed early proapoptotic effect as evidenced by several biological end-points of the apoptosis such as annexinV binding, DNA fragmentation and increase in sub-G0 DNA fraction and apoptotic bodies formation (Hoechst 33258 staining and SEM studies).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1768-3254
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier Masson SAS. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1356-66
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid.
pubmed:affiliation
Indian Institute of Integrative Medicine, CSIR, Canal Road, Jammu Tawi 180001, India.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't